Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Genetic inhibition of autophagy induces degenerative changes in mammalian tissues that
resemble those associated with aging, and normal and pathological aging are often …

All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …

Abstract SIRT1 (Sir2) is an NAD+-dependent deacetylase that plays critical roles in a broad
range of biological events, including metabolism, the immune response and ageing …

The nematode Caenorhabditis elegans ages and dies in a few weeks, but humans can live
for 100 years or more. Assuming that the ancestor we share with nematodes aged rapidly …

Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …

Ageing results from complex genetically and epigenetically programmed processes that are
elicited in part by noxious or stressful events that cause programmed cell death. Here, we …

While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …