Flavonoids: Overview of biosynthesis, biological activity, and current extraction techniques

S Liga, C Paul, F Péter - Plants, 2023 - mdpi.com
Recently, increased attention has been paid to natural sources as raw materials for the
development of new added-value products. Flavonoids are a large family of polyphenols …

Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: from mechanisms to therapeutics

R Thapa, M Afzal, A Goyal, G Gupta, AA Bhat… - Life sciences, 2024 - Elsevier
Glioblastoma (GBM) is the most prevalent and deadly primary brain tumor type, with a
discouragingly low survival rate and few effective treatments. An important function of the …

[HTML][HTML] CircRNAs: Pivotal modulators of TGF-β signalling in cancer pathogenesis

AA Bhat, G Gupta, R Dahiya, R Thapa, A Gahtori… - Non-coding RNA …, 2024 - Elsevier
The intricate molecular landscape of cancer pathogenesis continues to captivate
researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the …

ncRNAs and their impact on dopaminergic neurons: autophagy pathways in Parkinson's disease

R Thapa, E Moglad, M Afzal, G Gupta, AA Bhat… - Ageing Research …, 2024 - Elsevier
Parkinson's Disease (PD) is a complex neurological illness that causes severe motor and
non-motor symptoms due to a gradual loss of dopaminergic neurons in the substantia nigra …

Polyphenol-loaded nano-carriers for breast cancer therapy: a comprehensive review

AA Bhat, G Gupta, M Afzal, R Thapa, H Ali… - BioNanoScience, 2024 - Springer
Breast cancer remains a significant global health challenge, demanding innovative
therapeutic approaches. Polyphenols, a class of natural compounds widely distributed in …

Deciphering NF-kappaB pathways in smoking-related lung carcinogenesis

R Thapa, E Moglad, A Goyal, AA Bhat… - EXCLI …, 2024 - pmc.ncbi.nlm.nih.gov
One of the main causes of death worldwide is lung cancer, which is largely caused by
cigarette smoking. The crucial transcription factor NF-κB, which controls inflammatory …

Activated carbon-coated iron oxide magnetic nanocomposite (IONPs@ CtAC) loaded with morin hydrate for drug-delivery applications

Y Doğan, C Öziç, E Ertaş, A Baran, G Rosic… - Frontiers in …, 2024 - frontiersin.org
Cancer is a major disease that affects millions of people around the world every year. It
affects individuals of all ages, races, and backgrounds. Since drugs used to treat cancer …

[HTML][HTML] Therapeutic Potential of Natural Compounds to Modulate WNT/β-Catenin Signaling in Cancer: Current State of Art and Challenges

A Gajos-Michniewicz, M Czyz - International Journal of Molecular …, 2024 - mdpi.com
Targeted therapies and immunotherapies have improved the clinical outcome of cancer
patients; however, the efficacy of treatment remains frequently limited due to low …

Morin attenuates arsenic-induced toxicity in 3T3 embryonic fibroblast cells by suppressing oxidative stress, inflammation, and apoptosis: In vitro and silico evaluations

V Unsal, M Cicek, N Aktepe, E Oner - Toxicology Research, 2024 - academic.oup.com
This study aims to investigate the curative effects of Morin, a flavonoid, against arsenic
toxicity in 3T3 embryonic fibroblast cells and its effect on the molecular mechanisms of cells …

Noncoding RNAs as therapeutic targets in autophagy-related diabetic cardiomyopathy

MKB Break, RU Syed, W Hussein, S Alqarni… - … -Research and Practice, 2024 - Elsevier
Diabetic cardiomyopathy, a multifaceted complication of diabetes mellitus, remains a major
challenge in clinical management due to its intricate pathophysiology. Emerging evidence …