A guide to the organ-on-a-chip
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …
Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
Isothermal amplification of nucleic acids
Isothermal amplification of nucleic acids is a simple process that rapidly and efficiently
accumulates nucleic acid sequences at constant temperature. Since the early 1990s …
accumulates nucleic acid sequences at constant temperature. Since the early 1990s …
Microfluidic organs-on-chips
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …
methods that contains continuously perfused chambers inhabited by living cells arranged to …
Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences
Nearing 30 years since its introduction, 3D printing technology is set to revolutionize
research and teaching laboratories. This feature encompasses the history of 3D printing …
research and teaching laboratories. This feature encompasses the history of 3D printing …
Recent advances on cell culture platforms for in vitro drug screening and cell therapies: from conventional to microfluidic strategies
BD Cardoso, EMS Castanheira… - Advanced …, 2023 - Wiley Online Library
The clinical translations of drugs and nanomedicines depend on coherent pharmaceutical
research based on biologically accurate screening approaches. Since establishing the 2D in …
research based on biologically accurate screening approaches. Since establishing the 2D in …
Complex heterogeneous tissue constructs containing multiple cell types prepared by inkjet printing technology
T Xu, W Zhao, JM Zhu, MZ Albanna, JJ Yoo, A Atala - Biomaterials, 2013 - Elsevier
This study was designed to develop a versatile method for fabricating complex and
heterogeneous three-dimensional (3D) tissue constructs using simultaneous ink-jetting of …
heterogeneous three-dimensional (3D) tissue constructs using simultaneous ink-jetting of …
Microfluidic cell culture
Highlights•Microfluidic devices allow controlling culture conditions in the microscale.•They
have high potential for automation and parallelization, and facilitate simultaneous …
have high potential for automation and parallelization, and facilitate simultaneous …
Poly (dimethylsiloxane) as a material for fabricating microfluidic devices
JC McDonald, GM Whitesides - Accounts of chemical research, 2002 - ACS Publications
This Account summarizes techniques for fabrication and applications in biomedicine of
microfluidic devices fabricated in poly (dimethylsiloxane)(PDMS). The methods and …
microfluidic devices fabricated in poly (dimethylsiloxane)(PDMS). The methods and …
Soft lithography in biology and biochemistry
GM Whitesides, E Ostuni, S Takayama… - Annual review of …, 2001 - annualreviews.org
▪ Abstract Soft lithography, a set of techniques for microfabrication, is based on printing and
molding using elastomeric stamps with the patterns of interest in bas-relief. As a technique …
molding using elastomeric stamps with the patterns of interest in bas-relief. As a technique …