Glaucoma and the brain: trans-synaptic degeneration, structural change, and implications for neuroprotection

M Lawlor, H Danesh-Meyer, LA Levin… - Survey of …, 2018 - Elsevier
A recent hypothesis to enter the literature suggests that glaucoma is a neurodegenerative
disease. The basis for this has been the finding of central nervous system changes in …

Glaucoma: a degenerative optic neuropathy related to neuroinflammation?

S Mélik Parsadaniantz, A Réaux-le Goazigo… - Cells, 2020 - mdpi.com
Glaucoma is one of the leading causes of irreversible blindness in the world and remains a
major public health problem. To date, incomplete knowledge of this disease's …

Structural brain abnormalities in patients with primary open-angle glaucoma: a study with 3T MR imaging

WW Chen, N Wang, S Cai, Z Fang… - … & visual science, 2013 - iovs.arvojournals.org
Purpose.: Weexamined changes of the central nervous system in patients with advanced
primary open-angle glaucoma (POAG). Methods.: The clinical observational study included …

Structural and functional brain changes beyond visual system in patients with advanced glaucoma

P Frezzotti, A Giorgio, I Motolese, A De Leucio… - PloS one, 2014 - journals.plos.org
In order to test the hypothesis that in primary open angle glaucoma (POAG), an important
cause of irreversible blindness, a spreading of neurodegeneration occurs through the brain …

Changes of visual pathway and brain connectivity in glaucoma: a systematic review

R Nuzzi, L Dallorto, T Rolle - Frontiers in Neuroscience, 2018 - frontiersin.org
Background: Glaucoma is a leading cause of irreversible blindness worldwide. The
increasing interest in the involvement of the cortical visual pathway in glaucomatous patients …

Structural brain alterations in primary open angle glaucoma: a 3T MRI study

J Wang, T Li, BA Sabel, Z Chen, H Wen, J Li, X **e… - Scientific reports, 2016 - nature.com
Glaucoma is not only an eye disease but is also associated with degeneration of brain
structures. We now investigated the pattern of visual and non-visual brain structural changes …

Early changes of brain connectivity in primary open angle glaucoma

P Frezzotti, A Giorgio, F Toto, A De Leucio… - Human Brain …, 2016 - Wiley Online Library
Our aim was to assess in primary open angle glaucoma (POAG), a major cause of
irreversible blindness worldwide, whether diffuse brain changes recently shown in …

Residual vision activation and the brain-eye-vascular triad: Dysregulation, plasticity and restoration in low vision and blindness–a review

BA Sabel, J Flammer… - Restorative neurology and …, 2018 - content.iospress.com
Vision loss due to ocular diseases such as glaucoma, optic neuropathy, macular
degeneration, or diabetic retinopathy, are generally considered an exclusive affair of the …

Disturbed spontaneous brain activity pattern in patients with primary angle-closure glaucoma using amplitude of low-frequency fluctuation: a fMRI study

X Huang, YL Zhong, XJ Zeng, F Zhou… - Neuropsychiatric …, 2015 - Taylor & Francis
Objective The aim of this study is to use amplitude of low-frequency fluctuation (ALFF) as a
method to explore the local features of spontaneous brain activity in patients with primary …

Is there a link between open‐angle glaucoma and dementia? The Three‐City–Alienor Cohort

C Helmer, F Malet, MB Rougier… - Annals of …, 2013 - Wiley Online Library
Objective Previous research has suggested an association between dementia and
glaucoma through common risk factors or mechanisms. Our aim was to evaluate the …