In vitro anticancer activity of Eclipta alba whole plant extract on colon cancer cell HCT-116
Backgrounds Colon cancer is the third most deadly and one of the most diagnosed diseases
in the world. Although routine screening and early detection during last decades has …
in the world. Although routine screening and early detection during last decades has …
Regulation of Hsf1 and the heat shock response
D Pincus - HSF1 and molecular chaperones in biology and cancer, 2020 - Springer
The heat shock response (HSR) is characterized by the induction of molecular chaperones
following a sudden increase in temperature. In eukaryotes, the HSR comprises the set of …
following a sudden increase in temperature. In eukaryotes, the HSR comprises the set of …
Reactive oxygen species mediated apoptotic death of colon cancer cells: Therapeutic potential of plant derived alkaloids
Colorectal cancer (CRC) is one of the most deaths causing diseases worldwide. Several risk
factors including hormones like insulin and insulin like growth factors (eg, IGF-1) have been …
factors including hormones like insulin and insulin like growth factors (eg, IGF-1) have been …
A novel Huntington's disease assessment platform to support future drug discovery and development
J Wu, L Möhle, T Brüning, I Eiriz, M Rafehi… - International Journal of …, 2022 - mdpi.com
Huntington's disease (HD) is a lethal neurodegenerative disorder without efficient
therapeutic options. The inefficient translation from preclinical and clinical research into …
therapeutic options. The inefficient translation from preclinical and clinical research into …
Induction of monoamine oxidase A-mediated oxidative stress and impairment of NRF2-antioxidant defence response by polyphenol-rich fraction of Bergenia ligulata …
Prostate cancer (PCa) is a major cause of mortality and morbidity in men. Available
therapies yield limited outcome. We explored anti-PCa activity in a polyphenol-rich fraction …
therapies yield limited outcome. We explored anti-PCa activity in a polyphenol-rich fraction …
Potential benefits of phytochemicals from Azadirachta indica against neurological disorders
Azadirachta indica or Neem has been extensively used in the Indian traditional medical
system because of its broad range of medicinal properties. Neem contains many chemically …
system because of its broad range of medicinal properties. Neem contains many chemically …
[HTML][HTML] Molecular mechanisms and therapeutics for spinocerebellar ataxia type 2
The effective therapeutic treatment and the disease-modifying therapy for spinocerebellar
ataxia type 2 (SCA2)(a progressive hereditary disease caused by an expansion of …
ataxia type 2 (SCA2)(a progressive hereditary disease caused by an expansion of …
Bio-active compounds isolated from neem tree and their applications
R Sarah, B Tabassum, N Idrees… - Natural Bio-active …, 2019 - Springer
The extracts of different parts of neem tree (Azadirachta indica) have been well documented
for its pharmacological or medicinal properties and their wide applications by indigenous …
for its pharmacological or medicinal properties and their wide applications by indigenous …
NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells
Functional up-regulation of heat shock factor 1 (HSF1) activity through different
posttranslational modifications has been implicated in the survival and proliferation of …
posttranslational modifications has been implicated in the survival and proliferation of …
Withaferin a induces heat shock response and ameliorates disease progression in a mouse model of Huntington's disease
Impairment of proteostasis network is one of the characteristic features of many age-related
neurodegenerative disorders including autosomal dominantly inherited Huntington's …
neurodegenerative disorders including autosomal dominantly inherited Huntington's …