MicroRNAs as regulatory elements in immune system logic
A Mehta, D Baltimore - Nature Reviews Immunology, 2016 - nature.com
MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …
decisions. They act by negatively regulating the expression of key immune development …
Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge
T cell lineages are defined by specialized functions and differential expression of surface
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …
Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells
C Ma, M Han, B Heinrich, Q Fu, Q Zhang, M Sandhu… - Science, 2018 - science.org
INTRODUCTION Primary liver tumors and liver metastasis currently represent the leading
cause of cancer-related deaths. The liver intimately cross-talks with the gut and performs …
cause of cancer-related deaths. The liver intimately cross-talks with the gut and performs …
LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b
D Ti, H Hao, C Tong, J Liu, L Dong, J Zheng… - Journal of translational …, 2015 - Springer
Background Within the last few years, it has become evident that LPS-preconditioned
mesenchymal stromal cells (LPS pre-MSCs) show enhanced paracrine effects, including …
mesenchymal stromal cells (LPS pre-MSCs) show enhanced paracrine effects, including …
MicroRNA let-7 and viral infections: focus on mechanisms of action
MicroRNAs (miRNAs) are fundamental post-transcriptional modulators of several critical
cellular processes, a number of which are involved in host defense mechanisms. In …
cellular processes, a number of which are involved in host defense mechanisms. In …
Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer
Abnormal regulation and expression of microRNAs (miRNAs) has been documented in
various diseases including cancer. The miRNA let-7 (MIRLET7) family controls …
various diseases including cancer. The miRNA let-7 (MIRLET7) family controls …
The gene regulatory basis of bystander activation in CD8+ T cells
CD8+ T cells are classically recognized as adaptive lymphocytes based on their ability to
recognize specific foreign antigens and mount memory responses. However, recent studies …
recognize specific foreign antigens and mount memory responses. However, recent studies …
Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation
AC Wells, KA Hioki, CC Angelou, AC Lynch… - Nature …, 2023 - nature.com
The success of the CD8 T cell-mediated immune response against infections and tumors
depends on the formation of a long-lived memory pool, and the protection of effector cells …
depends on the formation of a long-lived memory pool, and the protection of effector cells …
Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis
Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous
system. Foxp3+ regulatory T (Treg) cells are reduced in frequency and dysfunctional in …
system. Foxp3+ regulatory T (Treg) cells are reduced in frequency and dysfunctional in …
Retinoic acid and retinoic acid receptors as pleiotropic modulators of the immune system
A Larange, H Cheroutre - Annual review of immunology, 2016 - annualreviews.org
Vitamin A is a multifunctional vitamin implicated in a wide range of biological processes. Its
control over the immune system and functions are perhaps the most pleiotropic not only for …
control over the immune system and functions are perhaps the most pleiotropic not only for …