Monitoring α-synuclein aggregation
Synucleinopathies, including Parkinson's disease (PD), dementia with Lewy Bodies (DLB),
and multiple system atrophy (MSA), are characterized by the misfolding and subsequent …
and multiple system atrophy (MSA), are characterized by the misfolding and subsequent …
Structural and functional insights into α-synuclein fibril polymorphism
Abnormal accumulation of aggregated α-synuclein (α-Syn) is seen in a variety of
neurodegenerative diseases, including Parkinson's disease (PD), multiple system atrophy …
neurodegenerative diseases, including Parkinson's disease (PD), multiple system atrophy …
Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies
Several studies have confirmed the α-synuclein real-time quaking-induced conversion (RT-
QuIC) assay to have high sensitivity and specificity for Parkinson's disease. However …
QuIC) assay to have high sensitivity and specificity for Parkinson's disease. However …
Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases
The intricate process of α-synuclein aggregation and fibrillization holds pivotal roles in
Parkinson's disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can …
Parkinson's disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can …
A multifunctional injectable hydrogel for boosted diabetic wound healing assisted by Quercetin-ZIF system
J Gong, H Wang, C **e, Y Dai, Y Wang… - Chemical Engineering …, 2024 - Elsevier
An important challenge in the chronic wound healing of diabetes is delayed healing stages
with impaired cellular functions, attributed to mitochondrial dysfunction and excessive …
with impaired cellular functions, attributed to mitochondrial dysfunction and excessive …
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology
Amyloid-forming proteins such α-synuclein and tau, which are implicated in Alzheimer's and
Parkinson's disease, can form different fibril structures or strains with distinct toxic properties …
Parkinson's disease, can form different fibril structures or strains with distinct toxic properties …
Inflammation promotes synucleinopathy propagation
TK Kim, EJ Bae, BC Jung, M Choi, SJ Shin… - … & molecular medicine, 2022 - nature.com
The clinical progression of neurodegenerative diseases correlates with the spread of
proteinopathy in the brain. The current understanding of the mechanism of proteinopathy …
proteinopathy in the brain. The current understanding of the mechanism of proteinopathy …
Peptide-based approaches to directly target alpha-synuclein in Parkinson's disease
SG Allen, RM Meade, LL White Stenner… - Molecular …, 2023 - Springer
Peptides and their mimetics are increasingly recognised as drug-like molecules, particularly
for intracellular protein-protein interactions too large for inhibition by small molecules, and …
for intracellular protein-protein interactions too large for inhibition by small molecules, and …
Comprehensive review on potential signaling pathways involving the transfer of α-synuclein from the gut to the brain that leads to Parkinson's disease
Parkinson's disease is the second most prevalent neurological disease after Alzheimer's.
Primarily, old age males are more affected than females. The aggregates of oligomeric forms …
Primarily, old age males are more affected than females. The aggregates of oligomeric forms …
Alpha-synuclein and mitochondrial dysfunction in Parkinson's disease: the emerging role of VDAC
Alpha-Synuclein (αSyn) is a protein whose function is still debated, as well as its role in
modulation of mitochondrial function in both physiological and pathological conditions …
modulation of mitochondrial function in both physiological and pathological conditions …