Small RNA sorting: matchmaking for Argonautes
Small RNAs directly or indirectly impact nearly every biological process in eukaryotic cells.
To perform their myriad roles, not only must precise small RNA species be generated, but …
To perform their myriad roles, not only must precise small RNA species be generated, but …
Making risc
T Kawamata, Y Tomari - Trends in biochemical sciences, 2010 - cell.com
It is well established that 20-to 30-nt small RNAs, including small interfering RNAs,
microRNAs and Piwi-interacting RNAs, play crucial roles in regulating gene expression and …
microRNAs and Piwi-interacting RNAs, play crucial roles in regulating gene expression and …
Re-evaluation of the roles of DROSHA, Exportin 5, and DICER in microRNA biogenesis
Biogenesis of canonical microRNAs (miRNAs) involves multiple steps: nuclear processing of
primary miRNA (pri-miRNA) by DROSHA, nuclear export of precursor miRNA (pre-miRNA) …
primary miRNA (pri-miRNA) by DROSHA, nuclear export of precursor miRNA (pre-miRNA) …
A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity
Dicer is a central enzyme in microRNA (miRNA) processing. We identified a Dicer-
independent miRNA biogenesis pathway that uses Argonaute2 (Ago2) slicer catalytic …
independent miRNA biogenesis pathway that uses Argonaute2 (Ago2) slicer catalytic …
Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants
Since the establishment of a canonical animal microRNA biogenesis pathway driven by the
RNase III enzymes Drosha and Dicer, an unexpected variety of alternative mechanisms that …
RNase III enzymes Drosha and Dicer, an unexpected variety of alternative mechanisms that …
miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity
Abstract microRNAs (miRNAs) act as sequence-specific guides for Argonaute (AGO)
proteins, which mediate posttranscriptional silencing of target messenger RNAs. Despite …
proteins, which mediate posttranscriptional silencing of target messenger RNAs. Despite …
Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis
Canonical animal microRNAs (miRNAs) are generated by sequential cleavage of precursor
substrates by the Drosha and Dicer RNase III enzymes. Several variant pathways exploit …
substrates by the Drosha and Dicer RNase III enzymes. Several variant pathways exploit …
Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes
Extracellular vesicles (EVs) encompass a variety of vesicles secreted into the extracellular
space. EVs have been implicated in promoting tumor metastasis, but the molecular …
space. EVs have been implicated in promoting tumor metastasis, but the molecular …
Deep-sequencing of human Argonaute-associated small RNAs provides insight into miRNA sorting and reveals Argonaute association with RNA fragments of diverse …
While several studies have focused on the relationship between individual miRNA loci or
classes of small RNA with human Argonaute (AGO) proteins, a comprehensive, global …
classes of small RNA with human Argonaute (AGO) proteins, a comprehensive, global …
EBV and human microRNAs co‐target oncogenic and apoptotic viral and human genes during latency
Epstein–Barr virus (EBV) controls gene expression to transform human B cells and maintain
viral latency. High‐throughput sequencing and crosslinking immunoprecipitation (HITS …
viral latency. High‐throughput sequencing and crosslinking immunoprecipitation (HITS …