The vascular endothelium is a monolayer of cells between the vessel lumen and the
vascular smooth muscle cells. Nitric oxide (NO) is a soluble gas continuously synthesized …

The endothelium forms an important part of the vasculature and is involved in promoting an
atheroprotective environment via the complementary actions of endothelial cell-derived …

The discovery that mammalian cells generate nitric oxide, a gas previously considered to be
merely an atmospheric pollutant, is providing important information about many biologic …

PART I THE ENDOTHELIUM has long been viewed as an inert cellophane-like membrane
that lines the circulatory system with its primary essential function being the maintenance of …

Abstract l-Arginine (Arg) is synthesised from glutamine, glutamate, and proline via the
intestinal-renal axis in humans and most other mammals (including pigs, sheep and rats) …

Endothelial dysfunction is a well established response to cardiovascular risk factors and
precedes the development of atherosclerosis. Endothelial dysfunction is involved in lesion …

Three isozymes of nitric oxide (NO) synthase (EC 1.14. 13.39) have been identified and the
cDNAs for these enzymes isolated. In humans, isozymes I (in neuronal and epithelial cells) …

To test the hypothesis that obesity/insulin resistance impairs both endothelium-dependent
vasodilation and insulin-mediated augmentation of endothelium-dependent vasodilation, we …

Objectives. This study attempted to assess whether coronary risk factors are associated with
endothelial dysfunction in the systemic arteries of asymptomatic men and women …

Background—Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor
of nitric oxide (NO) synthase. Because endothelial NO elaboration is impaired in …