Electrochemical methods for the analysis of clinically relevant biomolecules

M Labib, EH Sargent, SO Kelley - Chemical reviews, 2016 - ACS Publications
Rapid progress in identifying biomarkers that are hallmarks of disease has increased
demand for high-performance detection technologies. Implementation of electrochemical …

Rationally engineered nucleic acid architectures for biosensing applications

M **ao, W Lai, T Man, B Chang, L Li… - Chemical …, 2019 - ACS Publications
Development of biosensing platforms plays a key role in research settings for identification
of biomarkers and in clinical applications for diagnostics. Biosensors based on nucleic acids …

Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering

SO Kelley, CA Mirkin, DR Walt, RF Ismagilov… - Nature …, 2014 - nature.com
Rapid progress in identifying disease biomarkers has increased the importance of creating
high-performance detection technologies. Over the last decade, the design of many …

microRNA biosensors: Opportunities and challenges among conventional and commercially available techniques

T Kilic, A Erdem, M Ozsoz, S Carrara - Biosensors and Bioelectronics, 2018 - Elsevier
As being the most extensively studied, non-coding, evolutionary conserved, post-
transcriptional gene regulators of genome, microRNAs (miRNAs) have taken great attention …

Development of Nucleic‐Acid‐Based Electrochemical Biosensors for Clinical Applications

Z Zhang, P Sen, BR Adhikari, Y Li… - Angewandte …, 2022 - Wiley Online Library
Nucleic acids are remarkable molecules. In addition to Watson–Crick base pairing, the
different structural motifs of these molecules can bind non‐nucleic acid targets or catalyze …

Electrochemistry of nucleic acids

E Palecek, M Bartosik - Chemical Reviews, 2012 - ACS Publications
Large differences between the DPP responses of ss-and dsDNAs (Figure 4B) suggest that
the double-helical structure of the dsDNA is not significantly disturbed at the DME surface …

MicroRNAs as diagnostic and prognostic biomarkers in ischemic stroke—a comprehensive review and bioinformatic analysis

C Eyileten, Z Wicik, S De Rosa, D Mirowska-Guzel… - Cells, 2018 - mdpi.com
Stroke is the second-most common cause of death worldwide. The pathophysiology of
ischemic stroke (IS) is related to inflammation, atherosclerosis, blood coagulation, and …

An electrochemical clamp assay for direct, rapid analysis of circulating nucleic acids in serum

J Das, I Ivanov, L Montermini, J Rak, EH Sargent… - Nature …, 2015 - nature.com
The analysis of cell-free nucleic acids (cfNAs), which are present at significant levels in the
blood of cancer patients, can reveal the mutational spectrum of a tumour without the need for …

Dual-mode electrochemical analysis of microRNA-21 using gold nanoparticle-decorated MoS2 nanosheet

S Su, W Cao, W Liu, Z Lu, D Zhu, J Chao… - Biosensors and …, 2017 - Elsevier
The detection of microRNA plays an important role in early cancer diagnosis. Herein, a dual-
mode electronic biosensor was developed for microRNA-21 (miRNA-21) detection based on …

DNA clutch probes for circulating tumor DNA analysis

J Das, I Ivanov, EH Sargent… - Journal of the American …, 2016 - ACS Publications
Progress toward the development of minimally invasive liquid biopsies of disease is being
bolstered by breakthroughs in the analysis of circulating tumor DNA (ctDNA): DNA released …