Age-associated chronic inflammation is characterized by unresolved and uncontrolled
inflammation with multivariable low-grade, chronic and systemic responses that exacerbate …

Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …

Cancer constitutes a grave problem nowadays in view of the fact that it has become one of
the main causes of death worldwide. Poor clinical prognosis is presumably due to cancer …

Oxidative stress is a major cause of morbidity and mortality in human health and disease. In
this review, we focus on the Forkhead Box (Fox) subclass O3 (FoxO3), an extensively …

Background Endoplasmic reticulum (ER) stress is a basic cellular stress response that
maintains cellular protein homeostasis under endogenous or exogenous stimuli, which …

Endoplasmic reticulum (ER) stress is a mechanism that allows the protection of normal
cellular functions in response to both internal perturbations, such as accumulation of …

Modest levels of reactive oxygen species (ROS) are necessary for intracellular signaling,
cell division, and enzyme activation. These ROS are later eliminated by the body's …

Abstract Anterior gradient-2 (AGR2) protein mediates the formation, breakage and
isomerization of disulphide bonds during protein maturation in the endoplasmic reticulum …

Despite evident success in clarifying many important features of Alzheimer's disease (AD)
the efficient methods of its prevention and treatment are not yet available. The reasons are …

α-mangostin has been confirmed to promote the apoptosis of MG-63 cells, but its specific pro-
apoptosis mechanism in osteosarcoma (OS) remains further investigation. Here, we …