To correctly transfer information, neuronal networks need to continuously adjust their
synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of …

Voltage-and ligand-gated ion channels form the molecular basis of cellular excitability.
With> 400 members and accounting for∼ 1.5% of the human genome, ion channels are …

AMPA-type glutamate receptors (AMPARs) are responsible for a variety of processes in the
mammalian brain including fast excitatory neurotransmission, postsynaptic plasticity, or …

Information processing and storage in the brain rely on AMPA-receptors (AMPARs) and their
context-dependent dynamics in synapses and extra-synaptic sites. We found that distribution …

Native AMPA receptors (AMPARs) in the mammalian brain are macromolecular complexes
whose functional characteristics vary across the different brain regions and change during …

Astrocytes extensively infiltrate the neuropil to regulate critical aspects of synaptic
development and function. This process is regulated by transcellular interactions between …

Amyloid-beta (Aβ) plays a key role in the pathogenesis of Alzheimer's disease (AD), but little
is known about the proteoforms present in AD brain. We used high-resolution mass …

The filtration of blood in the kidney which is crucial for mammalian life is determined by the
slit-diaphragm, a cell-cell junction between the foot processes of renal podocytes. The slit …

Mitochondria have crucial roles in cellular energetics, metabolism, signalling and quality
control,,–. They contain around 1,000 different proteins that often assemble into complexes …

The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously
expressed membrane protein consisting of ion channel and protein kinase domains. TRPM7 …