Microglia are central players in brain innate immunity and have been the subject of
extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the …

The interaction between microglia and astrocytes significantly influences neuroinflammation.
Microglia/astrocytes, part of the neurovascular unit (NVU), are activated by various brain …

Early-life inflammation increases the risk for depression in later life. Here, we demonstrate
how early-life inflammation causes adolescent depressive-like symptoms: by altering the …

Synapses between engram cells are believed to be substrates for memory storage, and the
weakening or loss of these synapses leads to the forgetting of related memories. We found …

Proliferation and activation of microglia in the brain, concentrated around amyloid plaques,
is a prominent feature of Alzheimer's disease (AD). Human genetics data point to a key role …

Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia
are the principal immune cells of the brain, and the first to respond to the pathophysiological …

Alzheimer disease is more than a pure proteopathy. Chronic neuroinflammation stands out
during the pathogenesis of the disease and in turn modulates disease progression. The …

Sex has a role in the incidence and outcome of neurological illnesses, also influencing the
response to treatments. Neuroinflammation is involved in the onset and progression of …

Tumor-associated macrophages have emerged as crucial factors for metastases. Microglia
are indispensable components of the brain microenvironment and play vital roles in brain …

Glial cells, consisting of microglia, astrocytes, and oligodendrocyte lineage cells as their
major components, constitute a large fraction of the mammalian brain. Originally considered …