Many steps of RNA processing occur during transcription by RNA polymerases. Co-
transcriptional activities are deemed commonplace in prokaryotes, in which the lack of …

Bdellovibrio bacteriovorus, an obligate predatory Gram-negative bacterium that proliferates
inside and kills other Gram-negative bacteria, was discovered more than 60 years ago …

The organization of DNA into nucleosomes is a ubiquitous and ancestral feature that was
once thought to be exclusive to the eukaryotic domain of life. Intriguingly, several …

Histones are important chromatin-organizing proteins in eukaryotes and archaea. They form
superhelical structures around which DNA is wrapped. Recent studies have shown that …

In their natural habitats, organisms encounter numerous external stimuli and must be able to
sense and adapt to those stimuli to survive. Unlike mutations, epigenetic changes do not …

Histones are essential for genome compaction and transcription regulation in eukaryotes,
where they assemble into octamers to form the nucleosome core. In contrast, archaeal …

Disease-causing bacteria secrete numerous toxins to invade and subjugate their hosts.
Unlike many smaller toxins, the secretion machinery of most large toxins remains enigmatic …

Histone proteins have traditionally been thought to be restricted to eukaryotes and most
archaea, with eukaryotic nucleosomal histones deriving from their archaeal ancestors. In …

Genome regulation in eukaryotes revolves around the nucleosome, the fundamental
building block of eukaryotic chromatin. Its constituent parts, the four core histones (H3, H4 …

Common throughout life is the need to compact and organize the genome. Possible
mechanisms involved in this process include supercoiling, phase separation, charge …