Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

PH Lysaker, ML Pattison, BL Leonhardt… - World …, 2018 - Wiley Online Library
Poor insight in schizophrenia is prevalent across cultures and phases of illness. In this
review, we examine the recent research on the relationship of insight with behavior, mood …

The impact of delay in clozapine initiation on treatment outcomes in patients with treatment-resistant schizophrenia: a systematic review

P Shah, Y Iwata, E Plitman, EE Brown, F Caravaggio… - Psychiatry …, 2018 - Elsevier
Approximately one-third of patients with schizophrenia have treatment-resistant
schizophrenia (TR-SCZ), which is a condition characterized by suboptimal response to …

The “insight paradox” in schizophrenia: magnitude, moderators and mediators of the association between insight and depression

M Belvederi Murri, M Amore, P Calcagno… - Schizophrenia …, 2016 - academic.oup.com
The so-called “insight paradox” posits that among patients with schizophrenia higher levels
of insight are associated with increased levels of depression. Although different studies …

How can we improve the care of patients with schizophrenia in the real-world? A population-based cohort study of 456,003 patients

G Fond, B Falissard, P Nuss, C Collin, S Duret… - Molecular …, 2023 - nature.com
An important step to improve outcomes for patients with schizophrenia is to understand
treatment patterns in routine practice. The aim of the current study was to describe the long …

The multiple dimensions of insight in schizophrenia-spectrum disorders

M Belvederi Murri, M Amore - Schizophrenia bulletin, 2019 - academic.oup.com
The concept of insight is used to indicate the propensity of patients with schizophrenia and
other severe mental disorders to recognize their illness and engage in treatment. Thus …

Relationship between cannabis and psychosis: Reasons for use and associated clinical variables

A Mané, M Fernández-Expósito, D Bergé… - Psychiatry …, 2015 - Elsevier
The mechanism underneath the relationship between cannabis and psychosis remains
controversial, for which several hypotheses have been proposed, including cannabis as self …

Real-world predictors of relapse in patients with schizophrenia and schizoaffective disorder in a large health system

A Rivelli, V Fitzpatrick, M Nelson, K Laubmeier, C Zeni… - Schizophrenia, 2024 - nature.com
Schizophrenia is often characterized by recurring relapses, which are associated with a
substantial clinical and economic burden. Early identification of individuals at the highest …

Efficacy of transcranial direct current stimulation to improve insight in patients with schizophrenia: a systematic review and meta-analysis of randomized controlled …

O Adam, M Blay, AR Brunoni, HA Chang… - Schizophrenia …, 2022 - academic.oup.com
Abstract Background and Hypothesis Impaired insight into the illness and its consequences
is associated with poor outcomes in schizophrenia. While transcranial direct current …

Functioning, clinical severity, education and sex moderate the inverse relationship between insight and quality of life in patients with schizophrenia

G Barbalat, L Maréchal, J Plasse… - Schizophrenia …, 2024 - Elsevier
Background In schizophrenia, insight, the recognition that one has a medical illness that
requires treatment, has long been related to deteriorated quality of life, a phenomenon that …

Understanding the inverse relationship between age and psychotic symptoms: The role of borderline personality traits

EM Peters, K Yates, J DeVylder… - Acta Psychiatrica …, 2022 - Wiley Online Library
Objective There is a well‐established inverse relationship between age and positive
psychotic symptoms, both in patients with psychotic disorders and in general population …