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The Japanese Society of Hypertension guidelines for the management of hypertension (JSH 2019)
S Umemura, H Arima, S Arima, K Asayama… - Hypertension …, 2019 - nature.com
The Japanese Society of Hypertension (JSH) revised the Guidelines for the Management of
Hypertension 2014 (JSH 2014), and published the JSH 2019. In the development of the JSH …
Hypertension 2014 (JSH 2014), and published the JSH 2019. In the development of the JSH …
Animal models of hypertension: a scientific statement from the American Heart Association
Hypertension is the most common chronic disease in the world, yet the precise cause of
elevated blood pressure often cannot be determined. Animal models have been useful for …
elevated blood pressure often cannot be determined. Animal models have been useful for …
Genomics of hypertension: the road to precision medicine
The known genetic architecture of blood pressure now comprises> 30 genes, with rare
variants resulting in monogenic forms of hypertension or hypotension and> 1,477 common …
variants resulting in monogenic forms of hypertension or hypotension and> 1,477 common …
Salt sensitivity of blood pressure: a scientific statement from the American Heart Association
Hypertension is available at http://hyper. ahajournals. org DOI: 10.1161/HYP.
0000000000000047 e8 Hypertension September 2016 distributed trait. Therefore, defining …
0000000000000047 e8 Hypertension September 2016 distributed trait. Therefore, defining …
Evolving importance of kidney disease: from subspecialty to global health burden
In the past decade, kidney disease diagnosed with objective measures of kidney damage
and function has been recognised as a major public health burden. The population …
and function has been recognised as a major public health burden. The population …
[HTML][HTML] Gitelman syndrome: consensus and guidance from a kidney disease: improving global outcomes (KDIGO) controversies conference
Gitelman syndrome (GS) is a rare, salt-losing tubulopathy characterized by hypokalemic
metabolic alkalosis with hypomagnesemia and hypocalciuria. The disease is recessively …
metabolic alkalosis with hypomagnesemia and hypocalciuria. The disease is recessively …
Searching for missing heritability: designing rare variant association studies
Genetic studies have revealed thousands of loci predisposing to hundreds of human
diseases and traits, revealing important biological pathways and defining novel therapeutic …
diseases and traits, revealing important biological pathways and defining novel therapeutic …
Initial impact of the sequencing of the human genome
ES Lander - Nature, 2011 - nature.com
The sequence of the human genome has dramatically accelerated biomedical research.
Here I explore its impact, in the decade since its publication, on our understanding of the …
Here I explore its impact, in the decade since its publication, on our understanding of the …
Genetic diagnosis by whole exome capture and massively parallel DNA sequencing
Protein coding genes constitute only approximately 1% of the human genome but harbor
85% of the mutations with large effects on disease-related traits. Therefore, efficient …
85% of the mutations with large effects on disease-related traits. Therefore, efficient …
The genetics of quantitative traits: challenges and prospects
A major challenge in current biology is to understand the genetic basis of variation for
quantitative traits. We review the principles of quantitative trait locus map** and …
quantitative traits. We review the principles of quantitative trait locus map** and …