Advances in the Simulations of Enzyme Reactivity in the Dawn of the Artificial Intelligence Age
The study of natural enzyme catalytic processes at a molecular level can provide essential
information for a rational design of new enzymes, to be applied in more efficient and …
information for a rational design of new enzymes, to be applied in more efficient and …
Molecular Mechanisms for Stabilizing Biologics in the Solid State
Protein drugs exhibit challenges of biophysical and biochemical instability due to their
structural complexity and rich dynamics. Solid-state biologics aim to enhance stability by …
structural complexity and rich dynamics. Solid-state biologics aim to enhance stability by …
Efficient Synthesis of l-Asparagine by an Immobilized Three-Enzyme Cascade Reaction System
R Wang, W Song, H Xu, J Wen, W Wei… - ACS Sustainable …, 2025 - ACS Publications
l-Asparagine (l-Asn) is an important amino acid with broad applications in food, medicine,
fine chemicals, and environmental protection. However, its industrial production is limited by …
fine chemicals, and environmental protection. However, its industrial production is limited by …
Insights into mechanisms of MALT1 allostery from NMR and AlphaFold dynamic analyses
J Wallerstein, X Han, M Levkovets, D Lesovoy… - Communications …, 2024 - nature.com
Mucosa-associated lymphoid tissue lymphoma-translocation protein 1 (MALT1) is an
attractive target for the development of modulatory compounds in the treatment of lymphoma …
attractive target for the development of modulatory compounds in the treatment of lymphoma …
Loop engineering of cellobiose 2-epimerase from Dictyoglomus thermophilum for efficient synthesis of lactulose
Z Tao, LT Wang, WJ Tang, BR Zhang, S Wang… - International Journal of …, 2025 - Elsevier
Lactulose holds broad application due to its unique pharmaceutical and prebiotic properties.
Cellobiose 2-epimerase (CE) efficiently catalyzes the production of lactulose, offering an eco …
Cellobiose 2-epimerase (CE) efficiently catalyzes the production of lactulose, offering an eco …
Memory Effects Explain the Fractional Viscosity Dependence of Rates Associated with Internal Friction: Simple Models and Applications to Butane Dihedral Rotation
B Roy, VM Hridya, A Mukherjee - The Journal of Physical …, 2024 - ACS Publications
Barrier-crossing rates of biophysical processes, ranging from simple conformational
changes to protein folding, often deviate from the Kramers prediction of an inverse viscosity …
changes to protein folding, often deviate from the Kramers prediction of an inverse viscosity …
Unveiling the Catalytic Mechanism and Conformational Dynamics of Guinea Pig L-Asparaginase Type 1 for Leukemia Drug Design
In this study, we present a computational analysis of the catalytic properties of Guinea pig
asparaginase type 1 (or gpASNase1), an enzyme of mammalian origin that offers a …
asparaginase type 1 (or gpASNase1), an enzyme of mammalian origin that offers a …