Lymphatic transport maintains homeostatic health and is necessary for immune surveillance,
and yet lymphatic growth is often associated with solid tumour development and …

Leukocyte migration is a fundamental component of innate and adaptive immune responses
as it governs the recruitment and localization of these motile cells, which is crucial for …

Chemotactic cytokines—chemokines—control immune cell migration in the process of
initiation and resolution of inflammatory conditions as part of the body's defense system …

Tertiary lymphoid structures (TLSs) primarily constructed by multiple immune cells can
effectively enhance tumor immune responses, but expediting the formation of TLSs is still an …

Secondary lymphoid organs, such as lymph nodes, harbor highly specialized and
compartmentalized niches. These niches are optimized to facilitate the encounter of naive …

Single-cell technologies have recently allowed the identification of multiple lymphatic
endothelial cell (LEC) subsets in subcapsular, paracortical, medullary, and other lymph …

The chronic rejection responses and side effects of the systematic administration of
immunosuppressants are the main obstacles to heart allograft and patient survival. The …

T cell migration via afferent lymphatics to draining lymph nodes (dLNs) depends on
expression of CCR7 in T cells and CCL21 in the lymphatic vasculature. Once T cells have …

The chemokine network is comprised of a family of signal proteins that encode messages for
cells displaying chemokine G-protein coupled receptors (GPCRs). The diversity of effects on …

CCL21, a secondary lymphoid tissue chemokine, plays an important role in generating an
effective anti-tumor immune response. In this study, a genetically modified CCL21 was …