When the non-coding repeat expansion in the C9ORF72 gene was discovered to be the
most frequent cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis …

It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative
role in eliciting seizures. Among glutamate receptors, the roles of N-methyl-D-aspartate …

Defects in membrane trafficking are hallmarks of neurodegeneration. Rab GTPases are key
regulators of membrane trafficking. Alterations of Rab GTPases, or the membrane …

Dysregulation of early neurodevelopment is implicated in macrocephaly/autism disorders.
However, the mechanism underlying this dysregulation, particularly in human cells, remains …

Across all kingdoms in the tree of life, calcium (Ca2+) is an essential element used by cells
to respond and adapt to constantly changing environments. In multicellular organisms, it …

Membrane trafficking pathways are essential for the viability and growth of cells, and play a
major role in the interaction of cells with their environment. In this At a Glance article and …

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant familial
Parkinson's disease (PD), with pathogenic mutations enhancing LRRK2 kinase activity …

Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein containing two
catalytic domains: a Ras of complex proteins (Roc) G-domain and a kinase domain …

Rab proteins compose the largest family of small GTPases and control the different steps of
intracellular membrane traffic. More recently, they have been shown to also regulate cell …

Exosomes are small extracellular vesicles that originate from the intraluminal vesicles of
multivesicular bodies (MVBs). We previously reported that polarized Madin-Darby canine …