The therapeutic limitations such as insufficient efficacy, drug resistance, metastasis, and
undesirable side effects are frequently caused by the long duration monotherapy based on …

As traditional strategies for cancer treatment, some chemotherapy agents, such as
doxorubicin, oxaliplatin, cyclophosphamide, bortezomib, and paclitaxel exert their anti-tumor …

Background tRNA-derived small RNAs (tsRNAs) are newly discovered non-coding RNA,
which are generated from tRNAs and are reported to participate in several biological …

Leptomeningeal disease has become increasingly prevalent as novel therapeutic
interventions extend the survival of cancer patients. Although a majority of leptomeningeal …

Colorectal cancer (CRC), a leading cause of cancer-related mortalities globally, results from
the accumulation of multiple genetic and epigenetic alterations in the normal colonic and …

Gastrointestinal cancer (GIC) is a common malignant tumour of the digestive system that
seriously threatens human health. Due to the unique organ structure of the gastrointestinal …

Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been
extensively used in the clinic as the main cancer treatment either alone or as an adjuvant …

Exosomes are microvesicles secreted by body cells for intercellular communication. The
circular RNA circ_0000338 was found to be present in extracellular vesicles and improve …

Tumor hypoxia is confirmed to be associated with the formation of tumor
immunosuppression, a general feature of solid tumors, and thus attenuates the effectiveness …

Emerging evidence suggests that gut microbiota may influence the response to
chemotherapy. We sought to characterize the effects of 5 fluorouracil (5FU) chemotherapy …