Therapeutic miRNA and siRNA: moving from bench to clinic as next generation medicine

C Chakraborty, AR Sharma, G Sharma… - … Therapy-Nucleic Acids, 2017 - cell.com
In the past few years, therapeutic microRNA (miRNA) and small interfering RNA (siRNA) are
some of the most important biopharmaceuticals that are in commercial space as future …

Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach

G Mahmoodi Chalbatani, H Dana… - International journal …, 2019 - Taylor & Francis
Cancer is one of the most complex diseases that has resulted in multiple genetic disorders
and cellular abnormalities. Globally, cancer is the most common health concern disease that …

Efficacy, long-term toxicity, and mechanistic studies of gold nanorods photothermal therapy of cancer in xenograft mice

MRK Ali, MA Rahman, Y Wu, T Han… - Proceedings of the …, 2017 - National Acad Sciences
Gold nanorods (AuNRs)-assisted plasmonic photothermal therapy (AuNRs-PPTT) is a
promising strategy for combating cancer in which AuNRs absorb near-infrared light and …

High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma

CY **, L Du, AH Nuerlan, XL Wang… - Aging (albany …, 2020 - pmc.ncbi.nlm.nih.gov
Ribonucleotide reductase subunit M2 may play a role as a potential prognostic biomarker in
several cancers. In this study, we evaluated whether RRM2 gene expression is associated …

LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus

Y Jiang, W Cao, K Wu, X Qin, X Wang, Y Li… - Journal of Experimental …, 2019 - Springer
Abstract Background The lncRNA LINC00460 plays crucial roles in several epithelial
cancers, although its mechanisms of action differ greatly in different cellular contexts. In this …

Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and stemness-related subpopulations in liver cancer

DWH Ho, YM Tsui, KMF Sze, LK Chan, TT Cheung… - Cancer letters, 2019 - Elsevier
Hepatocellular carcinoma (HCC) is heterogeneous, rendering its current curative treatments
ineffective. The emergence of single-cell genomics represents a powerful strategy in …

Nanomedicine combats drug resistance in lung cancer

X Zheng, X Song, G Zhu, D Pan, H Li, J Hu… - Advanced …, 2024 - Wiley Online Library
Lung cancer is the second most prevalent cancer and the leading cause of cancer‐related
death worldwide. Surgery, chemotherapy, molecular targeted therapy, immunotherapy, and …

LncRNA AFAP1-AS1 supresses miR-139-5p and promotes cell proliferation and chemotherapy resistance of non-small cell lung cancer by competitively upregulating …

N Huang, W Guo, K Ren, W Li, Y Jiang, J Sun… - Frontiers in …, 2019 - frontiersin.org
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death
worldwide. This study aims to understand the underlying mechanism of lncRNA, actin …

RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma

X Jiang, Y Li, N Zhang, Y Gao, L Han, S Li, J Li, X Liu… - Cell & Bioscience, 2021 - Springer
Background As one of the most common malignancy, lung adenocarcinoma (LUAD) is
characterized by low 5-year survival rate. This research aimed to investigate the effects of …

Interpreting pathways to discover cancer driver genes with Moonlight

A Colaprico, C Olsen, MH Bailey, GJ Odom… - Nature …, 2020 - nature.com
Cancer driver gene alterations influence cancer development, occurring in oncogenes,
tumor suppressors, and dual role genes. Discovering dual role cancer genes is difficult …