Therapeutic miRNA and siRNA: moving from bench to clinic as next generation medicine
In the past few years, therapeutic microRNA (miRNA) and small interfering RNA (siRNA) are
some of the most important biopharmaceuticals that are in commercial space as future …
some of the most important biopharmaceuticals that are in commercial space as future …
Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach
G Mahmoodi Chalbatani, H Dana… - International journal …, 2019 - Taylor & Francis
Cancer is one of the most complex diseases that has resulted in multiple genetic disorders
and cellular abnormalities. Globally, cancer is the most common health concern disease that …
and cellular abnormalities. Globally, cancer is the most common health concern disease that …
Efficacy, long-term toxicity, and mechanistic studies of gold nanorods photothermal therapy of cancer in xenograft mice
MRK Ali, MA Rahman, Y Wu, T Han… - Proceedings of the …, 2017 - National Acad Sciences
Gold nanorods (AuNRs)-assisted plasmonic photothermal therapy (AuNRs-PPTT) is a
promising strategy for combating cancer in which AuNRs absorb near-infrared light and …
promising strategy for combating cancer in which AuNRs absorb near-infrared light and …
High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma
CY **, L Du, AH Nuerlan, XL Wang… - Aging (albany …, 2020 - pmc.ncbi.nlm.nih.gov
Ribonucleotide reductase subunit M2 may play a role as a potential prognostic biomarker in
several cancers. In this study, we evaluated whether RRM2 gene expression is associated …
several cancers. In this study, we evaluated whether RRM2 gene expression is associated …
LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus
Y Jiang, W Cao, K Wu, X Qin, X Wang, Y Li… - Journal of Experimental …, 2019 - Springer
Abstract Background The lncRNA LINC00460 plays crucial roles in several epithelial
cancers, although its mechanisms of action differ greatly in different cellular contexts. In this …
cancers, although its mechanisms of action differ greatly in different cellular contexts. In this …
Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and stemness-related subpopulations in liver cancer
DWH Ho, YM Tsui, KMF Sze, LK Chan, TT Cheung… - Cancer letters, 2019 - Elsevier
Hepatocellular carcinoma (HCC) is heterogeneous, rendering its current curative treatments
ineffective. The emergence of single-cell genomics represents a powerful strategy in …
ineffective. The emergence of single-cell genomics represents a powerful strategy in …
Nanomedicine combats drug resistance in lung cancer
Lung cancer is the second most prevalent cancer and the leading cause of cancer‐related
death worldwide. Surgery, chemotherapy, molecular targeted therapy, immunotherapy, and …
death worldwide. Surgery, chemotherapy, molecular targeted therapy, immunotherapy, and …
LncRNA AFAP1-AS1 supresses miR-139-5p and promotes cell proliferation and chemotherapy resistance of non-small cell lung cancer by competitively upregulating …
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death
worldwide. This study aims to understand the underlying mechanism of lncRNA, actin …
worldwide. This study aims to understand the underlying mechanism of lncRNA, actin …
RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma
Background As one of the most common malignancy, lung adenocarcinoma (LUAD) is
characterized by low 5-year survival rate. This research aimed to investigate the effects of …
characterized by low 5-year survival rate. This research aimed to investigate the effects of …
Interpreting pathways to discover cancer driver genes with Moonlight
Cancer driver gene alterations influence cancer development, occurring in oncogenes,
tumor suppressors, and dual role genes. Discovering dual role cancer genes is difficult …
tumor suppressors, and dual role genes. Discovering dual role cancer genes is difficult …