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[HTML][HTML] Recent progress in regulation of aging by insulin/IGF-1 signaling in Caenorhabditis elegans
Caenorhabditis elegans has been used as a major model organism to identify genetic
factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF …
factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF …
CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells
Background: Cisplatin is one of the frontline anticancer agents. However, development of
cisplatin-resistance limits the therapeutic efficacy of cisplatin-based treatment. The …
cisplatin-resistance limits the therapeutic efficacy of cisplatin-based treatment. The …
[HTML][HTML] Microtubule-associated serine/threonine (MAST) kinases in development and disease
M Rumpf, S Pautz, B Drebes, FW Herberg… - International Journal of …, 2023 - mdpi.com
Microtubule-Associated Serine/Threonine (MAST) kinases represent an evolutionary
conserved branch of the AGC protein kinase superfamily in the kinome. Since the discovery …
conserved branch of the AGC protein kinase superfamily in the kinome. Since the discovery …
A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling
Abstract Insulin/IGF-1 signaling (IIS) regulates various physiological aspects in numerous
species. In Caenorhabditis elegans, mutations in the daf-2/insulin/IGF-1 receptor …
species. In Caenorhabditis elegans, mutations in the daf-2/insulin/IGF-1 receptor …
The MAST kinase KIN-4 carries out mitotic entry functions of Greatwall in C. elegans
L Roumbo, B Ossareh-Nazari, S Vigneron… - The EMBO …, 2025 - embopress.org
MAST-like, or Greatwall (Gwl), an atypical protein kinase related to the evolutionarily
conserved MAST kinase family, is crucial for cell cycle control during mitotic entry …
conserved MAST kinase family, is crucial for cell cycle control during mitotic entry …
Genetic analysis of daf-18/PTEN missense mutants for starvation resistance and developmental regulation during Caenorhabditis elegans L1 arrest
Mutations in the well-known tumor suppressor PTEN are observed in many cancers. PTEN
is a dual-specificity phosphatase that harbors lipid and protein-phosphatase activities. The …
is a dual-specificity phosphatase that harbors lipid and protein-phosphatase activities. The …
Potential roles of MEK1 on aging in Argopecten scallops
K Yuan, X Lu, J Ning, M Chen, Q Wang… - Frontiers in Marine …, 2022 - frontiersin.org
Dual specificity mitogen-activated protein kinase kinase 1 (MEK1) has been found to
regulate aging through the Ras/Raf/MEK/ERK cascade in terrestrial animals. However, few …
regulate aging through the Ras/Raf/MEK/ERK cascade in terrestrial animals. However, few …
Genetic screens identified dual roles of microtubule-associated serine threonine kinase and CREB within a single thermosensory neuron in the regulation of …
Animals integrate sensory stimuli presented at the past and present, assess the changes in
their surroundings and navigate themselves toward preferred environment. Identifying the …
their surroundings and navigate themselves toward preferred environment. Identifying the …
MAST4 promotes primary ciliary resorption through phosphorylation of Tctex-1
K Sakaji, S Ebrahimiazar, Y Harigae… - Life Science …, 2023 - life-science-alliance.org
The primary cilium undergoes cell cycle–dependent assembly and disassembly.
Dysregulated ciliary dynamics are associated with several pathological conditions called …
Dysregulated ciliary dynamics are associated with several pathological conditions called …
Genetic screens identified dual roles of MAST kinase and CREB within a single thermosensory neuron in the regulation of C. elegans thermotaxis behavior
S Nakano, A Nakayama, H Kuroyanagi, R Yamashiro… - bioRxiv, 2022 - biorxiv.org
Animals integrate sensory stimuli presented at the past and present, assess the changes in
their surroundings and navigate themselves toward preferred environment. Identifying the …
their surroundings and navigate themselves toward preferred environment. Identifying the …