Multifunctional biomolecule nanostructures for cancer therapy

J Wang, Y Li, G Nie - Nature Reviews Materials, 2021 - nature.com
Biomolecule-based nanostructures are inherently multifunctional and harbour diverse
biological activities, which can be explored for cancer nanomedicine. The supramolecular …

Immunomodulatory nanosystems

X Feng, W Xu, Z Li, W Song, J Ding… - Advanced science, 2019 - Wiley Online Library
Immunotherapy has emerged as an effective strategy for the prevention and treatment of a
variety of diseases, including cancer, infectious diseases, inflammatory diseases, and …

The interaction between nanoparticles and immune system: application in the treatment of inflammatory diseases

J Liu, Z Liu, Y Pang, H Zhou - Journal of Nanobiotechnology, 2022 - Springer
Nanoparticle (NP) is an emerging tool applied in the biomedical field. With combination of
different materials and adjustment of their physical and chemical properties, nanoparticles …

The biology of T regulatory type 1 cells and their therapeutic application in immune-mediated diseases

MG Roncarolo, S Gregori, R Bacchetta, M Battaglia… - Immunity, 2018 - cell.com
Thirty years ago, one of the first types of CD4+ T regulatory cells was discovered and named
T regulatory type 1 (Tr1) cells. Tr1 cells represent a distinct population of T cells, which are …

Targeted modulation of immune cells and tissues using engineered biomaterials

P Yousefpour, K Ni, DJ Irvine - Nature reviews bioengineering, 2023 - nature.com
Therapies modulating the immune system offer the prospect of treating a wide range of
conditions including infectious diseases, cancer and autoimmunity. Biomaterials can …

Antigen-specific therapeutic approaches for autoimmunity

P Serra, P Santamaria - Nature biotechnology, 2019 - nature.com
The main function of the immune system in health is to protect the host from infection by
microbes and parasites. Because immune responses to nonself bear the risk of unleashing …

Therapeutic induction of antigen-specific immune tolerance

JE Kenison, NA Stevens, FJ Quintana - Nature Reviews Immunology, 2024 - nature.com
The development of therapeutic approaches for the induction of robust, long-lasting and
antigen-specific immune tolerance remains an important unmet clinical need for the …

Emerging nano‐/microapproaches for cancer immunotherapy

Y Mi, CT Hagan IV, BG Vincent, AZ Wang - Advanced Science, 2019 - Wiley Online Library
Cancer immunotherapy has achieved remarkable clinical efficacy through recent advances
such as chimeric antigen receptor‐T cell (CAR‐T) therapy, immune checkpoint blockade …

DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation

X Huang, JZ Williams, R Chang, Z Li, CE Burnett… - Nature …, 2021 - nature.com
Biomaterials can improve the safety and presentation of therapeutic agents for effective
immunotherapy, and a high level of control over surface functionalization is essential for …

Therapies for type 1 diabetes: current scenario and future perspectives

V Pathak, NM Pathak, CL O'Neill… - Clinical Medicine …, 2019 - journals.sagepub.com
Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing β cells
located in the endocrine pancreas in areas known as islets of Langerhans. The current …