Extending the “one strain many compounds”(OSMAC) principle to marine microorganisms

S Romano, SA Jackson, S Patry, ADW Dobson - Marine drugs, 2018 - mdpi.com
Genomic data often highlights an inconsistency between the number of gene clusters
identified using bioinformatic approaches as potentially producing secondary metabolites …

Synthetic biology and metabolic engineering of actinomycetes for natural product discovery

E Palazzotto, Y Tong, SY Lee, T Weber - Biotechnology Advances, 2019 - Elsevier
Actinomycetes are one of the most valuable sources of natural products with industrial and
medicinal importance. After more than half a century of exploitation, it has become …

Reproducible molecular networking of untargeted mass spectrometry data using GNPS

AT Aron, EC Gentry, KL McPhail, LF Nothias… - Nature protocols, 2020 - nature.com
Abstract Global Natural Product Social Molecular Networking (GNPS) is an interactive online
small molecule–focused tandem mass spectrometry (MS2) data curation and analysis …

Natural product drug discovery in the genomic era: realities, conjectures, misconceptions, and opportunities

RH Baltz - Journal of Industrial Microbiology and Biotechnology, 2019 - academic.oup.com
Natural product discovery from microorganisms provided important sources for antibiotics,
anti-cancer agents, immune-modulators, anthelminthic agents, and insecticides during a …

Evolutionary dynamics of natural product biosynthesis in bacteria

MG Chevrette, K Gutiérrez-García… - Natural product …, 2020 - pubs.rsc.org
Covering: 2008 up to 2019 The forces of biochemical adaptive evolution operate at the level
of genes, manifesting in complex phenotypes and the global biodiversity of proteins and …

Antiproliferative and Antioxidative Bioactive Compounds in Extracts of Marine-Derived Endophytic Fungus Talaromyces purpureogenus

M Kumari, S Taritla, A Sharma… - Frontiers in …, 2018 - frontiersin.org
Endophytic fungi are now recognized as sources of pharmacologically beneficial, novel
bioactive compounds. This study was carried out to evaluate antiproliferative and …

[HTML][HTML] Recent Advances in Strategies for Activation and Discovery/Characterization of Cryptic Biosynthetic Gene Clusters in Streptomyces

CT Nguyen, D Dhakal, VTT Pham, HT Nguyen… - Microorganisms, 2020 - mdpi.com
Streptomyces spp. are prolific sources of valuable natural products (NPs) that are of great
interest in pharmaceutical industries such as antibiotics, anticancer chemotherapeutics …

Secondary metabolites released by the rhizosphere bacteria Arthrobacter oxydans and Kocuria rosea enhance plant availability and soil–plant transfer of germanium …

R Schwabe, C Dittrich, J Kadner, CHR Senges… - Chemosphere, 2021 - Elsevier
Here, we explore effects of metallophore-producing rhizobacteria on the plant availability of
germanium (Ge) and rare earth elements (REEs). Five isolates of the four species …

Streptomyces Volatile Compounds Influence Exploration and Microbial Community Dynamics by Altering Iron Availability

SE Jones, CA Pham, MP Zambri, J McKillip… - MBio, 2019 - journals.asm.org
Bacteria and fungi produce a wide array of volatile organic compounds (VOCs), and these
can act as chemical cues or as competitive tools. Recent work has shown that the VOC …

A Streptomyces species from the ginseng rhizosphere exhibits biocontrol potential

J Huang, X Li, X Zhan, S Pan, C Pan, J Li… - Plant …, 2024 - academic.oup.com
Plants and their associated microbes live in complicated, changeable, and unpredictable
environments. They usually interact with each other in many ways through multidimensional …