The biological effects of the bisphosphonates (BPs) as inhibitors of calcification and bone
resorption were first described in the late 1960s. In the 50 years that have elapsed since …

Recently, targeting metabolic reprogramming has emerged as a potential therapeutic
approach for fighting cancer. Sterol regulatory element binding protein-2 (SREBP-2), a basic …

Metastatic bone disease develops as a result of the many interactions between tumour cells
and bone cells. This leads to disruption of normal bone metabolism, with the increased …

Cancer is a multifaceted global disease. Transformation of a normal to a malignant cell takes
several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming …

Mevalonate pathway is an important metabolic pathway which plays a key role in multiple
cellular processes by synthesizing sterol isoprenoids, such as cholesterol, and non-sterol …

Background Ovarian suppression plus tamoxifen is a standard adjuvant treatment in
premenopausal women with endocrine-responsive breast cancer. Aromatase inhibitors are …

Abstract Learning Objectives After completing this course, the reader will be able to:
Describe the mechanism of action of first-generation and nitrogen-containing …

Abstract Bisphosphonates (BP) prevent, reduce, and delay cancer-related skeletal
complications in patients, and have substantially decreased the prevalence of such events …

The presence of bone metastases is indicative of disseminated disease and typically
indicates a short-term prognosis in cancer patients. Palliation of symptoms is the primary …

Background Treatment with bisphosphonates decreases bone loss and can increase
disease-free survival in patients with breast cancer. The aim of our study was to assess the …