Novel small molecule therapeutic agents for Alzheimer disease: Focusing on BACE1 and multi-target directed ligands
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that effects 50 million
people worldwide. In this review, AD pathology and the development of novel therapeutic …
people worldwide. In this review, AD pathology and the development of novel therapeutic …
BACE-1 inhibitors: from recent single-target molecules to multitarget compounds for Alzheimer's disease: miniperspective
The amyloid hypothesis has long been the central dogma in drug discovery for Alzheimer's
disease (AD), leading to many small-molecule and biological drug candidates. One major …
disease (AD), leading to many small-molecule and biological drug candidates. One major …
Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease
K Rajasekhar, M Chakrabarti… - Chemical …, 2015 - pubs.rsc.org
Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …
Synthesis and in-silico studies of some new thiazole carboxamide derivatives with theoretical investigation
N A. Kheder, H Ather, D R. Emam… - Polycyclic Aromatic …, 2024 - Taylor & Francis
Based on the tremendous pharmacological activities of compounds containing thiazole and
carboxamide moieties, the current study aims to prepare new series of thiazole, pyrazole …
carboxamide moieties, the current study aims to prepare new series of thiazole, pyrazole …
Screening Techniques for Drug Discovery in Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive and
irreversible impairment of memory and other cognitive functions of the aging brain …
irreversible impairment of memory and other cognitive functions of the aging brain …
Per-residue energy footprints-based pharmacophore modeling as an enhanced in silico approach in drug discovery: a case study on the identification of novel β …
A further refinement to our previously published “target-bound pharmacophore modeling
approach” is reported herein. Instead of relying on “random” pharmacophores—which is the …
approach” is reported herein. Instead of relying on “random” pharmacophores—which is the …
Design, synthesis and biological evaluation of tyrosinase-targeting PROTACs
D Fu, Y Yuan, F Qin, Y Xu, X Cui, G Li, S Yao… - European Journal of …, 2021 - Elsevier
The human tyrosinase is the most prominent therapeutic target for pigmentary skin
disorders. However, the overwhelming majority efforts have been devoted to search …
disorders. However, the overwhelming majority efforts have been devoted to search …
Fused 1, 4‐Dihydropyridines and Their Corresponding Pyridines: Synthesis, Molecular Modeling and Cholinesterase Inhibition
Abstract Novel series of fused 1, 4‐dihydropyridine derivatives were designed and
synthesized. Oxidized to the corresponding pyridines were these dihydropyridines. Both …
synthesized. Oxidized to the corresponding pyridines were these dihydropyridines. Both …
Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics …
Overexpression of the efflux pump P-glycoprotein (P-gp) is one of the important mechanisms
of multidrug resistance (MDR) in many tumor cells. In this study, 26 novel 5-oxo …
of multidrug resistance (MDR) in many tumor cells. In this study, 26 novel 5-oxo …
N‐(2‐(Piperazin‐1‐yl)phenyl)arylamide Derivatives as β‐Secretase (BACE1) Inhibitors: Simple Synthesis by Ugi Four‐Component Reaction and Biological …
A novel series of N‐(2‐(piperazin‐1‐yl) phenyl) aryl carboxamide derivatives were simply
synthesized by Ugi‐multicomponent reaction as β‐secretase (BACE1) inhibitors. The …
synthesized by Ugi‐multicomponent reaction as β‐secretase (BACE1) inhibitors. The …