Selective neuronal loss in ischemic stroke and cerebrovascular disease

JC Baron, H Yamauchi, M Fujioka… - Journal of Cerebral …, 2014 - journals.sagepub.com
As a sequel of brain ischemia, selective neuronal loss (SNL)—as opposed to pannecrosis
(ie infarction)—is attracting growing interest, particularly because it is now detectable in vivo …

Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion

FA Pinho-Ribeiro, L Deng, DV Neel, O Erdogan… - Nature, 2023 - nature.com
The meninges are densely innervated by nociceptive sensory neurons that mediate pain
and headache,. Bacterial meningitis causes life-threatening infections of the meninges and …

Neuronal death after hemorrhagic stroke in vitro and in vivo shares features of ferroptosis and necroptosis

M Zille, SS Karuppagounder, Y Chen, PJ Gough… - Stroke, 2017 - ahajournals.org
Background and Purpose—Intracerebral hemorrhage leads to disability or death with few
established treatments. Adverse outcomes after intracerebral hemorrhage result from …

The impact of endothelial cell death in the brain and its role after stroke: a systematic review

M Zille, M Ikhsan, Y Jiang, J Lampe, J Wenzel… - Cell …, 2019 - pmc.ncbi.nlm.nih.gov
The supply of oxygen and nutrients to the brain is vital for its function and requires a complex
vascular network that, when disturbed, results in profound neurological dysfunction. As part …

Ischemia-selective cardioprotection by malonate for ischemia/reperfusion injury

HA Prag, D Aksentijevic, A Dannhorn, AV Giles… - Circulation …, 2022 - ahajournals.org
Background: Inhibiting SDH (succinate dehydrogenase), with the competitive inhibitor
malonate, has shown promise in ameliorating ischemia/reperfusion injury. However, key for …

RTN1-C mediates cerebral ischemia/reperfusion injury via ER stress and mitochondria-associated apoptosis pathways

L Gong, Y Tang, R An, M Lin, L Chen, J Du - Cell death & disease, 2017 - nature.com
The reticulon family has been found to induce apoptosis, inhibit axon regeneration and
regulate protein trafficking. However, little is known about the mechanisms of how reticulon …

Potential anxiolytic and antidepressant-like effects of luteolin in a chronic constriction injury rat model of neuropathic pain: Role of oxidative stress, neurotrophins, and …

T Mokhtari, M Lu, AEM El-Kenawy - International Immunopharmacology, 2023 - Elsevier
This study aimed to examine the effects of luteolin (LUT) on chronic neuropathic pain (NP)-
induced mood disorders (ie, anxiety and depression) by regulating oxidative stress …

Exosomes from miRNA‐126‐modified endothelial progenitor cells alleviate brain injury and promote functional recovery after stroke

J Wang, S Chen, W Zhang, Y Chen… - CNS Neuroscience & …, 2020 - Wiley Online Library
Aims We previously showed that the protective effects of endothelial progenitor cells (EPCs)‐
released exosomes (EPC‐EXs) on endothelium in diabetes. However, whether EPC‐EXs …

Lactate dehydrogenase A mediated histone lactylation induced the pyroptosis through targeting HMGB1

X Yao, C Li - Metabolic Brain Disease, 2023 - Springer
Cerebral ischemia (CI), as the cerebrovascular disease with the highest incidence rate, is
treated by limited intravenous thrombolysis and intravascular therapy to recanalize the …

The stroke preclinical assessment network: rationale, design, feasibility, and stage 1 results

PD Lyden, F Bosetti, MA Diniz, A Rogatko, JI Koenig… - Stroke, 2022 - ahajournals.org
Cerebral ischemia and reperfusion initiate cellular events in brain that lead to neurological
disability. Investigating these cellular events provides ample targets for develo** new …