Host genetics and infectious disease: new tools, insights and translational opportunities
Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
Tuberculosis phenotypic and genotypic drug susceptibility testing and immunodiagnostics: a review
KA Yusoof, JI Garcia, A Schami… - Frontiers in …, 2022 - frontiersin.org
Tuberculosis (TB), considered an ancient disease, is still killing one person every 21
seconds. Diagnosis of Mycobacterium tuberculosis (M. tb) still has many challenges …
seconds. Diagnosis of Mycobacterium tuberculosis (M. tb) still has many challenges …
Single-cell eQTL models reveal dynamic T cell state dependence of disease loci
Non-coding genetic variants may cause disease by modulating gene expression. However,
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …
Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease
Multimodal T cell profiling can enable more precise characterization of elusive cell states
underlying disease. Here, we integrated single-cell RNA and surface protein data from …
underlying disease. Here, we integrated single-cell RNA and surface protein data from …
A positively selected FBN1 missense variant reduces height in Peruvian individuals
On average, Peruvian individuals are among the shortest in the world. Here we show that
Native American ancestry is associated with reduced height in an ethnically diverse group of …
Native American ancestry is associated with reduced height in an ethnically diverse group of …
[HTML][HTML] Comprehensive identification of immuno-related transcriptional signature for active pulmonary tuberculosis by integrated analysis of array and single cell RNA …
Y Xu, Y Tan, X Zhang, M Cheng, J Hu, J Liu, X Chen… - Journal of Infection, 2022 - Elsevier
Background Tuberculosis (TB) continues to be a major cause of morbidity and mortality
worldwide. However, the molecular mechanism underlying immune response to human …
worldwide. However, the molecular mechanism underlying immune response to human …
Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture
The heritability of susceptibility to tuberculosis (TB) disease has been well recognized. Over
100 genes have been studied as candidates for TB susceptibility, and several variants were …
100 genes have been studied as candidates for TB susceptibility, and several variants were …
Who transmits tuberculosis to whom: a cross-sectional analysis of a cohort study in Lima, Peru
L Trevisi, MB Brooks, MC Becerra… - American Journal of …, 2024 - atsjournals.org
Rationale: The persistent burden of tuberculosis (TB) disease emphasizes the need to
identify individuals with TB for treatment and those at a high risk of incident TB for …
identify individuals with TB for treatment and those at a high risk of incident TB for …
The awesome power of human genetics of infectious disease
Since the identification of sickle cell trait as a heritable form of resistance to malaria,
candidate gene studies, linkage analysis paired with sequencing, and genome-wide …
candidate gene studies, linkage analysis paired with sequencing, and genome-wide …
Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas
Latin Americans are underrepresented in genetic studies, increasing disparities in
personalized genomic medicine. Despite available genetic data from thousands of Latin …
personalized genomic medicine. Despite available genetic data from thousands of Latin …