G-quadruplexes at telomeres: friend or foe?
TM Bryan - Molecules, 2020 - mdpi.com
Telomeres are DNA-protein complexes that cap and protect the ends of linear
chromosomes. In almost all species, telomeric DNA has a G/C strand bias, and the short …
chromosomes. In almost all species, telomeric DNA has a G/C strand bias, and the short …
Orchestrating nucleic acid–protein interactions at chromosome ends: telomerase mechanisms come into focus
Telomerase is a special reverse transcriptase ribonucleoprotein dedicated to the synthesis
of telomere repeats that protect chromosome ends. Among reverse transcriptases …
of telomere repeats that protect chromosome ends. Among reverse transcriptases …
A hybrid de novo genome assembly of the honeybee, Apis mellifera, with chromosome-length scaffolds
A Wallberg, I Bunikis, OV Pettersson, MB Mosbech… - BMC genomics, 2019 - Springer
Background The ability to generate long sequencing reads and access long-range linkage
information is revolutionizing the quality and completeness of genome assemblies. Here we …
information is revolutionizing the quality and completeness of genome assemblies. Here we …
The i-motif as a molecular target: more than a complementary DNA secondary structure
SL Brown, S Kendrick - Pharmaceuticals, 2021 - mdpi.com
Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …
The telomere/telomerase system in chronic inflammatory diseases. Cause or effect?
Telomeres are specialized nucleoprotein structures located at the end of linear
chromosomes and telomerase is the enzyme responsible for telomere elongation …
chromosomes and telomerase is the enzyme responsible for telomere elongation …
Diversity and evolution of telomeric motifs and telomere DNA organization in insects
VA Lukhtanov, EA Pazhenkova - Biological Journal of the …, 2023 - academic.oup.com
The telomerase mechanism and telomeric motifs are vital for maintaining chromosome
integrity. Their functions are conserved in eukaryotic organisms; therefore, it is not surprising …
integrity. Their functions are conserved in eukaryotic organisms; therefore, it is not surprising …
Telomere organization and the interstitial telomeric sites involvement in insects and vertebrates chromosome evolution
Telomere has a central role in chromosomal stability events. Chromosome ends organized
in telomere-loop prevent activation of DNA damage response (DDR) mechanisms, thus …
in telomere-loop prevent activation of DNA damage response (DDR) mechanisms, thus …
RNA biology of disease-associated microsatellite repeat expansions
Microsatellites, or simple tandem repeat sequences, occur naturally in the human genome
and have important roles in genome evolution and function. However, the expansion of …
and have important roles in genome evolution and function. However, the expansion of …
Long-read sequencing reveals intra-species tolerance of substantial structural variations and new subtelomere formation in C. elegans
Long-read sequencing technologies have contributed greatly to comparative genomics
among species and can also be applied to study genomics within a species. In this study, to …
among species and can also be applied to study genomics within a species. In this study, to …
What are the functional roles of Piwi proteins and piRNAs in insects?
Simple Summary Three small RNA pathways, representing miRNAs, siRNAs and piRNAs,
exist in insects. Of the three pathways, piRNAs and Piwi proteins appear to have the most …
exist in insects. Of the three pathways, piRNAs and Piwi proteins appear to have the most …