Cancer is a disorder that rigorously affects the human population worldwide. There is a
steady demand for new remedies to both treat and prevent this life-threatening sickness due …

Naphthalene, a cytotoxic moiety, is an extensively explored aromatic conjugated system with
applications in various pathophysiological conditions viz. anticancer, antimicrobial, anti …

A growing solid tumor relies on a develo** vasculature to meet its needs in terms of
oxygen, nutrients, depuration, etc. This implies that if the vascular bed that has developed …

Considering the intrinsic toxicities of transition metals, their incorporation into drug therapies
must operate at minimal amounts while ensuring adequate catalytic activity within complex …

Using a Ni (dppf) catalyst generated in situ, Heck cross-coupling of aryl pivalates with a
variety of olefin partners has been accomplished. This method represents one of the first …

A structure–activity relationship (SAR) guided design of novel tubulin polymerization
inhibitors has resulted in a series of benzo [b] furans with exceptional potency toward cancer …

We describe the synthesis and biological evaluation of a series of tubulin polymerization
inhibitors that contain the 1, 2, 4-triazole ring to retain the bioactive configuration afforded by …

Cornbretastatin A-4 (CA-4) is one of the most potent antinnitotic and antiangiogenic agents
of natural origin. It has displayed potent antitunnor effect in a wide variety of preclinical …

The transcription factor nuclear factor kappaB (NF-κB), which regulates expression of
numerous antiinflammatory genes as well as genes that promote development of the …

The combretastatins are isolated from South African tree combretum caffrum kuntze. The
lead compound combretastatin A-4 has displayed remarkable cytotoxic effect in a wide …