The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Background Traditional risk factors are insufficient to explain all cases of coronary artery
disease (CAD) in patients with diabetes mellitus (DM). Advanced glycation end-products …

During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent
adducts with the plasma proteins through a non-enzymatic process known as glycation …

Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Glycation is both a physiological and pathological process which mainly affects proteins,
nucleic acids and lipids. Exogenous and endogenous glycation produces deleterious …

In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively
produced and accumulated in the circulating blood and various tissues. AGEs also …

Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

Diminished bioavailability of nitric oxide (NO), the gaseous signaling molecule involved in
the regulation of numerous vital biological functions, contributes to the development and …

Advanced glycation end products (AGEs) are proteins or lipids that become glycated after
exposure to sugars. AGEs are prevalent in the diabetic vasculature and contribute to the …