Endoplasmic reticulum stress signals in the tumour and its microenvironment
Protein handling, modification and folding in the endoplasmic reticulum (ER) are tightly
regulated processes that determine cell function, fate and survival. In several tumour types …
regulated processes that determine cell function, fate and survival. In several tumour types …
Roles of XBP1s in transcriptional regulation of target genes
SM Park, TI Kang, JS So - Biomedicines, 2021 - mdpi.com
The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that
plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum (ER) …
plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum (ER) …
[HTML][HTML] Endoplasmic reticulum stress signaling in cancer cells
SA Oakes - The American journal of pathology, 2020 - Elsevier
To survive, cancer cells must resist numerous internal and environmental insults associated
with neoplasia that jeopardize proteostasis within the endoplasmic reticulum (ER). Solid and …
with neoplasia that jeopardize proteostasis within the endoplasmic reticulum (ER). Solid and …
Alternative approaches to target Myc for cancer treatment
The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL,
which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc …
which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc …
Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production
Z Yang, Y Huo, S Zhou, J Guo, X Ma, T Li, C Fan… - Cell Metabolism, 2022 - cell.com
A hostile microenvironment in tumor tissues disrupts endoplasmic reticulum homeostasis
and induces the unfolded protein response (UPR). A chronic UPR in both cancer cells and …
and induces the unfolded protein response (UPR). A chronic UPR in both cancer cells and …
The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance
Tumour cells endure both oncogenic and environmental stresses during cancer
progression. Transformed cells must meet increased demands for protein and lipid …
progression. Transformed cells must meet increased demands for protein and lipid …
Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors
Despite substantial advances in targeting mutant KRAS, tumor resistance to KRAS inhibitors
(KRASi) remains a major barrier to progress. Here, we report proteostasis reprogramming as …
(KRASi) remains a major barrier to progress. Here, we report proteostasis reprogramming as …
Pharmacological targeting of the unfolded protein response for disease intervention
Accumulation of unfolded proteins at the endoplasmic reticulum (ER) is a salient attribute of
many human diseases including obesity, liver disorders, cancer, diabetes and …
many human diseases including obesity, liver disorders, cancer, diabetes and …
Endoplasmic reticulum stress—a key guardian in cancer
W Zhang, Y Shi, L Oyang, S Cui, S Li, J Li, L Liu… - Cell Death …, 2024 - nature.com
Endoplasmic reticulum stress (ERS) is a cellular stress response characterized by excessive
contraction of the endoplasmic reticulum (ER). It is a pathological hallmark of many …
contraction of the endoplasmic reticulum (ER). It is a pathological hallmark of many …
Homeostasis control in health and disease by the unfolded protein response
Cells rely on the endoplasmic reticulum (ER) to fold and assemble newly synthesized
transmembrane and secretory proteins—essential for cellular structure–function and for both …
transmembrane and secretory proteins—essential for cellular structure–function and for both …