Antibiotic tolerance among clinical isolates: mechanisms, detection, prevalence, and significance
AT Deventer, CE Stevens, A Stewart… - Clinical Microbiology …, 2024 - journals.asm.org
Antibiotic treatment failures in the absence of resistance are not uncommon. Recently,
attention has grown around the phenomenon of antibiotic tolerance, an underappreciated …
attention has grown around the phenomenon of antibiotic tolerance, an underappreciated …
Altered serine metabolism promotes drug tolerance in Mycobacterium abscessus via a WhiB7-mediated adaptive stress response
Mycobacterium abscessus is an emerging opportunistic pathogen responsible for chronic
lung diseases, especially in patients with cystic fibrosis. Treatment failure of M. abscessus …
lung diseases, especially in patients with cystic fibrosis. Treatment failure of M. abscessus …
Bacterial biofilms: Pathogenesis, monitoring, treatment approaches and associated challenges
Recognition of the fact that bacterial biofilm might contribute to the development of diseases
has prompted a greater emphasis on identifying conditions, that could be linked to the …
has prompted a greater emphasis on identifying conditions, that could be linked to the …
Disrupting central carbon metabolism increases Β-lactam antibiotic susceptibility in Vibrio Cholerae
Antibiotic tolerance, the ability of bacteria to sustain viability in the presence of typically
bactericidal antibiotics for extended time periods, is an understudied contributor to treatment …
bactericidal antibiotics for extended time periods, is an understudied contributor to treatment …
Novel daptomycin tolerance and resistance mutations in methicillin-resistant Staphylococcus aureus from adaptive laboratory evolution
It has been shown recently in a number of in vitro laboratory evolution experiments that
under repetitive antibiotic exposure, bacterial populations can adapt quickly to the treatment …
under repetitive antibiotic exposure, bacterial populations can adapt quickly to the treatment …
Multidrug tolerance conferred by loss-of-function mutations in anti-sigma factor RshA of Mycobacterium abscessus
Low-level drug resistance in noncanonical pathways can constitute step**stones toward
acquisition of high-level on-target resistance mutations in the clinic. To capture these …
acquisition of high-level on-target resistance mutations in the clinic. To capture these …
Mutation in the two-component system regulator YycH leads to daptomycin tolerance in methicillin-resistant Staphylococcus aureus upon evolution with a population …
Adaptive laboratory evolution (ALE) is a useful tool to study the evolution of antibiotic
tolerance in bacterial populations under diverse environmental conditions. The role of …
tolerance in bacterial populations under diverse environmental conditions. The role of …
Phenotypic resistant single-cell characteristics under recurring ampicillin antibiotic exposure in Escherichia coli
S Kollerová, L Jouvet, J Smelková, S Zunk-Parras… - …, 2024 - journals.asm.org
Non-heritable, phenotypic drug resistance toward antibiotics challenges antibiotic therapies.
Characteristics of such phenotypic resistance have implications for the evolution of heritable …
Characteristics of such phenotypic resistance have implications for the evolution of heritable …
Proteomics and transcriptomics uncover key processes for elasnin tolerance in methicillin-resistant Staphylococcus aureus
Elasnin is a new antibiofilm compound that was recently reported to have excellent activity
against methicillin-resistant Staphylococcus aureus (MRSA) biofilms. In this study, we …
against methicillin-resistant Staphylococcus aureus (MRSA) biofilms. In this study, we …