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Doxorubicin—an agent with multiple mechanisms of anticancer activity
Doxorubicin (DOX) constitutes the major constituent of anti-cancer treatment regimens
currently in clinical use. However, the precise mechanisms of DOX's action are not fully …
currently in clinical use. However, the precise mechanisms of DOX's action are not fully …
ROS in cancer therapy: the bright side of the moon
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. It is now well accepted that moderate …
evolved as regulators of important signaling pathways. It is now well accepted that moderate …
Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring
Tumor microbiota can produce active metabolites that affect cancer and immune cell
signaling, metabolism, and proliferation. Here, we explore tumor and gut microbiome …
signaling, metabolism, and proliferation. Here, we explore tumor and gut microbiome …
Cellular functions of the protein kinase ATM and their relevance to human disease
The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
Molecular mechanisms of oxidative stress in asthma
The lungs are exposed to reactive oxygen species oxygen (ROS) produced as a result of
inhalation of oxygen, as well as smoke and other air pollutants. Cell metabolism and the …
inhalation of oxygen, as well as smoke and other air pollutants. Cell metabolism and the …
Ageing as a risk factor for neurodegenerative disease
Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer
disease (AD) and Parkinson disease (PD). One in ten individuals aged≥ 65 years has AD …
disease (AD) and Parkinson disease (PD). One in ten individuals aged≥ 65 years has AD …
ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4
Ferroptosis is a newly characterized form of programmed cell death, which is driven by the
lethal accumulation of lipid peroxides catalyzed by the intracellular bioactive iron. Targeted …
lethal accumulation of lipid peroxides catalyzed by the intracellular bioactive iron. Targeted …
From NASH to HCC: current concepts and future challenges
Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …
Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis
Abstract Hydrogen peroxide (H2O2) is a major reactive oxygen species in unicellular and
multicellular organisms, and is produced extracellularly in response to external stresses and …
multicellular organisms, and is produced extracellularly in response to external stresses and …
Mitochondrial H2O2 release does not directly cause damage to chromosomal DNA
Abstract Reactive Oxygen Species (ROS) derived from mitochondrial respiration are
frequently cited as a major source of chromosomal DNA mutations that contribute to cancer …
frequently cited as a major source of chromosomal DNA mutations that contribute to cancer …