Long COVID science, research and policy
Long COVID represents the constellation of post-acute and long-term health effects caused
by SARS-CoV-2 infection; it is a complex, multisystem disorder that can affect nearly every …
by SARS-CoV-2 infection; it is a complex, multisystem disorder that can affect nearly every …
Long COVID: a clinical update
Summary Post-COVID-19 condition (also known as long COVID) is generally defined as
symptoms persisting for 3 months or more after acute COVID-19. Long COVID can affect …
symptoms persisting for 3 months or more after acute COVID-19. Long COVID can affect …
Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection
The mechanisms of postacute medical conditions and unexplained symptoms after SARS-
CoV-2 infection [Long Covid (LC)] are incompletely understood. There is growing evidence …
CoV-2 infection [Long Covid (LC)] are incompletely understood. There is growing evidence …
Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment
C Greene, R Connolly, D Brennan, A Laffan… - Nature …, 2024 - nature.com
Vascular disruption has been implicated in coronavirus disease 2019 (COVID-19)
pathogenesis and may predispose to the neurological sequelae associated with long …
pathogenesis and may predispose to the neurological sequelae associated with long …
[HTML][HTML] Mechanisms of long COVID and the path toward therapeutics
Long COVID, a type of post-acute sequelae of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2)(PASC) defined by medically unexplained symptoms following …
coronavirus 2 (SARS-CoV-2)(PASC) defined by medically unexplained symptoms following …
Infection and chronic disease activate a systemic brain-muscle signaling axis
Infections and neurodegenerative diseases induce neuroinflammation, but affected
individuals often show nonneural symptoms including muscle pain and muscle fatigue. The …
individuals often show nonneural symptoms including muscle pain and muscle fatigue. The …
Persistent SARS-CoV-2 infection: significance and implications
HM Machkovech, AM Hahn, JG Wang… - The Lancet Infectious …, 2024 - thelancet.com
SARS-CoV-2 causes persistent infections in a subset of individuals, which is a major clinical
and public health problem that should be prioritised for further investigation for several …
and public health problem that should be prioritised for further investigation for several …
An aberrant immune–epithelial progenitor niche drives viral lung sequelae
The long-term physiological consequences of respiratory viral infections, particularly in the
aftermath of the COVID-19 pandemic—termed post-acute sequelae of SARS-CoV-2 (PASC) …
aftermath of the COVID-19 pandemic—termed post-acute sequelae of SARS-CoV-2 (PASC) …
SARS-CoV-2 S1 subunit produces a protracted priming of the neuroinflammatory, physiological, and behavioral responses to a remote immune challenge: A role for …
MG Frank, JB Ball, S Hopkins, T Kelley… - Brain, Behavior, and …, 2024 - Elsevier
Long COVID is a major public health consequence of COVID-19 and is characterized by
multiple neurological and neuropsychatric symptoms. SARS-CoV-2 antigens (eg, spike S1 …
multiple neurological and neuropsychatric symptoms. SARS-CoV-2 antigens (eg, spike S1 …
Emerging SARS-CoV-2 resistance after antiviral treatment
Importance Previous studies have identified mutations in SARS-CoV-2 strains that confer
resistance to nirmatrelvir, yet how often this resistance arises and its association with …
resistance to nirmatrelvir, yet how often this resistance arises and its association with …