Hypercholesterolaemia leads to cholesterol accumulation in macrophages and other
immune cells, which promotes inflammatory responses, including augmentation of Toll-like …

Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

High-density lipoproteins (HDLs) protect against atherosclerosis by removing excess
cholesterol from macrophages through the ATP-binding cassette transporter A1 (ABCA1) …

With cardiovascular disease being the leading cause of morbidity and mortality worldwide,
effective and cost-efficient therapies to reduce cardiovascular risk are highly needed. Lipids …

Detailed studies in the past two decades have shown that redox active metals like iron (Fe),
copper (Cu), chromium (Cr), cobalt (Co) and other metals undergo redox cycling reactions …

Obesity, especially of the abdominal type, is a health problem that constitutes metabolic
syndrome and increases the incidence of various diseases, including diabetes …

Several prospective epidemiological studies have shown that there is a clear inverse
relationship between serum high-density lipoprotein-cholesterol (HDL-C) concentrations …

Apolipoprotein AI (ApoA-I), the major protein component of high-density lipoproteins (HDL)
is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune …

High-density lipoproteins (HDLs) represent a family of particle characterized by the
presence of apolipoprotein AI (apoA-I) and by their ability to transport cholesterol from …

Infection and inflammation induce the acutephase response (APR), leading to multiple
alterations in lipid and lipoprotein metabolism. Plasma triglyceride levels increase from …