Advances in metal-induced oxidative stress and human disease
Detailed studies in the past two decades have shown that redox active metals like iron (Fe),
copper (Cu), chromium (Cr), cobalt (Co) and other metals undergo redox cycling reactions …
copper (Cu), chromium (Cr), cobalt (Co) and other metals undergo redox cycling reactions …
Cholesterol, inflammation and innate immunity
Hypercholesterolaemia leads to cholesterol accumulation in macrophages and other
immune cells, which promotes inflammatory responses, including augmentation of Toll-like …
immune cells, which promotes inflammatory responses, including augmentation of Toll-like …
Dysfunctional HDL and atherosclerotic cardiovascular disease
RS Rosenson, HB Brewer Jr, BJ Ansell… - Nature reviews …, 2016 - nature.com
High-density lipoproteins (HDLs) protect against atherosclerosis by removing excess
cholesterol from macrophages through the ATP-binding cassette transporter A1 (ABCA1) …
cholesterol from macrophages through the ATP-binding cassette transporter A1 (ABCA1) …
[HTML][HTML] The role of lipids and lipoproteins in atherosclerosis
MRF Linton, PG Yancey, SS Davies, WG Jerome… - Endotext …, 2019 - ncbi.nlm.nih.gov
Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …
[PDF][PDF] Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host
W Khovidhunkit, MS Kim, RA Memon… - The Journal of …, 2004 - pdfs.semanticscholar.org
Infection and inflammation induce the acutephase response (APR), leading to multiple
alterations in lipid and lipoprotein metabolism. Plasma triglyceride levels increase from …
alterations in lipid and lipoprotein metabolism. Plasma triglyceride levels increase from …
Antiinflammatory properties of HDL
There are several well-documented functions of high-density lipoprotein (HDL) that may
explain the ability of these lipoproteins to protect against atherosclerosis. The best …
explain the ability of these lipoproteins to protect against atherosclerosis. The best …
Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer
M Matsuda, I Shimomura - Obesity research & clinical practice, 2013 - Elsevier
Obesity, especially of the abdominal type, is a health problem that constitutes metabolic
syndrome and increases the incidence of various diseases, including diabetes …
syndrome and increases the incidence of various diseases, including diabetes …
Serum amyloid A, the major vertebrate acute‐phase reactant
CM Uhlar, AS Whitehead - European journal of biochemistry, 1999 - Wiley Online Library
The serum amyloid A (SAA) family comprises a number of differentially expressed
apolipoproteins, acute‐phase SAAs (A‐SAAs) and constitutive SAAs (C‐SAAs). A‐SAAs are …
apolipoproteins, acute‐phase SAAs (A‐SAAs) and constitutive SAAs (C‐SAAs). A‐SAAs are …
Copper, oxidative stress, and human health
JY Uriu-Adams, CL Keen - Molecular aspects of medicine, 2005 - Elsevier
Copper (Cu), a redox active metal, is an essential nutrient for all species studied to date.
During the past decade, there has been increasing interest in the concept that marginal …
During the past decade, there has been increasing interest in the concept that marginal …
Paraoxonase and atherosclerosis
PN Durrington, B Mackness… - … , thrombosis, and vascular …, 2001 - Am Heart Assoc
There is considerable evidence that the antioxidant activity of high density lipoprotein (HDL)
is largely due to the paraoxonase-1 (PON1) located on it. Experiments with transgenic PON1 …
is largely due to the paraoxonase-1 (PON1) located on it. Experiments with transgenic PON1 …