Allosteric modulation of G protein-coupled receptor signaling
G protein-coupled receptors (GPCRs), the largest family of transmembrane proteins,
regulate a wide array of physiological processes in response to extracellular signals …
regulate a wide array of physiological processes in response to extracellular signals …
G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery
M Zhang, T Chen, X Lu, X Lan, Z Chen… - Signal Transduction and …, 2024 - nature.com
G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and
an important class of drug targets, play a role in maintaining numerous physiological …
an important class of drug targets, play a role in maintaining numerous physiological …
Positive allosteric modulation of a GPCR ternary complex
The activation of a G protein–coupled receptor (GPCR) leads to the formation of a ternary
complex between agonist, receptor, and G protein that is characterized by high-affinity …
complex between agonist, receptor, and G protein that is characterized by high-affinity …
Concerted conformational changes control metabotropic glutamate receptor activity
N Lecat-Guillet, RB Quast, H Liu, E Bourrier… - Science …, 2023 - science.org
Allosteric modulators bear great potential to fine-tune neurotransmitter action. Promising
targets are metabotropic glutamate (mGlu) receptors, which are associated with numerous …
targets are metabotropic glutamate (mGlu) receptors, which are associated with numerous …
Cholesterol in Class C GPCRs: Role, relevance, and localization
G-protein coupled receptors (GPCRs), one of the largest superfamilies of cell-surface
receptors, are heptahelical integral membrane proteins that play critical roles in virtually …
receptors, are heptahelical integral membrane proteins that play critical roles in virtually …
Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function
Abstract Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion
molecules involved in numerous physiological functions. aGPCRs have large multi-domain …
molecules involved in numerous physiological functions. aGPCRs have large multi-domain …
Stepwise activation of a metabotropic glutamate receptor
Metabotropic glutamate receptors belong to a family of G protein-coupled receptors that are
obligate dimers and possess a large extracellular ligand-binding domain that is linked via a …
obligate dimers and possess a large extracellular ligand-binding domain that is linked via a …
Structural analysis and conformational dynamics of a holo-adhesion GPCR reveal interplay between extracellular and transmembrane domains
ABSTRACT Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion
molecules involved in numerous physiological functions. aGPCRs have large multi-domain …
molecules involved in numerous physiological functions. aGPCRs have large multi-domain …
[HTML][HTML] Step-wise activation of a Family C GPCR
Metabotropic glutamate receptors belong to a family of G protein-coupled receptors that are
obligate dimers and possess a large extracellular ligand-binding domain (ECD) that is …
obligate dimers and possess a large extracellular ligand-binding domain (ECD) that is …
Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization
The metabotropic glutamate receptors (mGluRs) are neuromodulatory family CG protein
coupled receptors which assemble as dimers and allosterically couple extracellular ligand …
coupled receptors which assemble as dimers and allosterically couple extracellular ligand …