A molecular biology–based taxonomy has been proposed for pheochromocytoma and
paraganglioma (PPGL). Data from the Cancer Genome Atlas revealed clinically relevant …

Mitochondrial complex II (CII), also called succinate dehydrogenase (SDH), is a central
purveyor of the reprogramming of metabolic and respiratory adaptation in response to …

Succinate dehydrogenase (SDH) has been classically considered a mitochondrial enzyme
with the unique property to participate in both the citric acid cycle and the electron transport …

The succinate dehydrogenase (SDH) complex is a key respiratory enzyme composed of four
subunits: SDHA, SDHB, SDHC and SDHD. Remarkably, immunohistochemistry for SDHB …

Mitochondrial succinate dehydrogenase (SDH), also known as electron transport chain
(ETC) Complex II, is the only enzyme complex engaged in both oxidative phosphorylation …

Gastrointestinal stromal tumors (GISTs) are potentially malignancies that can occur
anywhere in the digestive tract. Tyrosine kinase inhibitors (TKIs) such as imatinib have …

Despite the established role of SDHB/SDHA immunohistochemistry as a valuable tool to
identify patients at risk for familial succinate dehydrogenase-related pheochromocytoma …

The paraganglioma (PGL) syndromes types 1–5 are autosomal dominant disorders
characterized by familial predisposition to PGLs, phaeochromocytomas (PCs), renal cell …

Paragangliomas (PGL) develop from the parasympathetic system in the head and neck (HN)
and arise primarily in four distinct areas: Carotid body, vagal, middle ear, and larynx …

Gastrointestinal stromal tumors are rare malignancies involving the intestinal tract. They are
now easily recognized using standard immunohistochemistry. Management in the past was …