The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves
as a cornerstone in cellular signaling, regulating physiological and pathological processes …

Natural Killer (NK) cells are cytotoxic lymphocytes of the innate immune system and play a
critical role in anti-viral and anti-tumor responses. NK cells develop in the bone marrow from …

The Janus tyrosine kinase (JAK) family of non-receptor tyrosine kinases includes four
isoforms (JAK1, JAK2, JAK3, and TYK2) and is responsible for signal transduction …

Natural killer (NK) cells are lymphocytes primarily involved in innate immunity and possess
important functional properties in anti-viral and anti-tumor responses; thus, these cells have …

The JAK/STAT pathway is a conserved metazoan signaling system that transduces cues
from extracellular cytokines into transcriptional changes in the nucleus. JAK/STAT signaling …

Cytokines are critical mediators of diverse immune and inflammatory diseases. Targeting
cytokines and cytokine receptors with biologics has revolutionized the treatment of many of …

JAK inhibitors have been developed following the discovery of the JAK2V617F in 2005 as
the driver mutation of the majority of non-BCR-ABL1 myeloproliferative neoplasms (MPNs) …

The importance of diversity and cellular specialization is clear for many reasons, from
population-level diversification, to improved resiliency to unforeseen stresses, to unique …

The distinct clinical features of myelofibrosis (MF) have been attributed in part to
dysregulated inflammatory cytokine production. Circulating cytokine levels are elevated in …

Despite the importance of intestinal stem cells (ISCs) for epithelial maintenance, there is
limited understanding of how immune-mediated damage affects ISCs and their niche. We …