The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis
M Carmena, M Wheelock, H Funabiki… - … reviews Molecular cell …, 2012 - nature.com
Successful cell division requires the precise and timely coordination of chromosomal,
cytoskeletal and membrane trafficking events. These processes are regulated by the …
cytoskeletal and membrane trafficking events. These processes are regulated by the …
A molecular view of kinetochore assembly and function
Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …
Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore
In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore,
a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches …
a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches …
The Aurora B kinase in chromosome bi-orientation and spindle checkpoint signaling
Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player
in chromosome segregation. As part of a macromolecular complex known as the …
in chromosome segregation. As part of a macromolecular complex known as the …
Tension directly stabilizes reconstituted kinetochore-microtubule attachments
Kinetochores are macromolecular machines that couple chromosomes to dynamic
microtubule tips during cell division, thereby generating force to segregate the …
microtubule tips during cell division, thereby generating force to segregate the …
The kinetochore
IM Cheeseman - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …
cells. The central player in this process is the macromolecular kinetochore structure, which …
The four causes: the functional architecture of centromeres and kinetochores
Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …
Sensing centromere tension: Aurora B and the regulation of kinetochore function
Maintaining genome integrity during cell division requires regulated interactions between
chromosomes and spindle microtubules. To ensure that daughter cells inherit the correct …
chromosomes and spindle microtubules. To ensure that daughter cells inherit the correct …
Mitosis
JR McIntosh - Cold Spring Harbor perspectives in …, 2016 - cshperspectives.cshlp.org
All eukaryotic cells prepare for cell division by forming a “mitotic spindle”—a bipolar machine
made from microtubules (MTs) and many associated proteins. This device organizes the …
made from microtubules (MTs) and many associated proteins. This device organizes the …
Kinase and phosphatase cross-talk at the kinetochore
AT Saurin - Frontiers in cell and developmental biology, 2018 - frontiersin.org
Multiple kinases and phosphatases act on the kinetochore to control chromosome
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …