Elastin is the polymeric protein responsible for the physiologically important properties of
extensibility and elastic recoil of cardiovascular, pulmonary and many other tissues. In spite …

Aims Bicuspid aortic valve (BAV) is associated with aortic wall alterations. We aimed to
detect any correlation between aortic elasticity and genetic and biomolecular patterns of …

Genome-wide association studies found genetic variations with modulatory effects for
intracranial aneurysm (IA) formations in European and Japanese populations. We aimed to …

Background Fragmentation of the tunica media is a hallmark of intracranial aneurysm
formation, often leading to aneurysmal progression and subsequent rupture. The objective …

Variation in the elastin gene (ELN) may contribute to connective tissue disease beyond the
known disease associations of supravalvar aortic stenosis and cutis laxa. Exome data from …

Background The relationship between the apolipoprotein E (APOE) polymorphism and
intracranial aneurysms has previously only been studied in Russia and Japan but not in …

Background: The presence of an intracranial aneurysm (IA) is thought to have a genetic
origin. The genetic association studies (GAS) that investigated the association between IA …

Elastin is a major polymeric protein of the extracellular matrix, providing critical properties of
extensibility and elastic recoil. The rs2071307 genomic polymorphism, resulting in the …

Genetic Risk Assessment of Elastin Gene Polymorphisms with Intracranial Aneurysm in
Koreans Page 1 Genetic Risk Assessment of Elastin Gene Polymorphisms with Intracranial …

摘要目的: 探讨Stanford A 型主动脉夹层(AD) 升主动脉中层弹性蛋白和弹力纤维变化. 方法:
收集10 例Stanford A 型AD 患者术中获取的升主动脉管壁组织标本与10 例脑死亡捐献手术中或 …