Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review
Neuroinflammation is proposed as one of the mechanisms by which Alzheimer's disease
pathology, including amyloid-β plaques, leads to neuronal death and dysfunction. Increases …
pathology, including amyloid-β plaques, leads to neuronal death and dysfunction. Increases …
Brain insulin resistance at the crossroads of metabolic and cognitive disorders in humans
Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …
accumulated that insulin action in the brain produces multiple behavioral and metabolic …
Neuroinflammation: microglia and T cells get ready to tango
In recent years, many paradigms concerning central nervous system (CNS) immunology
have been challenged and shifted, including the discovery of CNS-draining lymphatic …
have been challenged and shifted, including the discovery of CNS-draining lymphatic …
Aging effects on DNA methylation modules in human brain and blood tissue
Background Several recent studies reported aging effects on DNA methylation levels of
individual CpG dinucleotides. But it is not yet known whether aging-related consensus …
individual CpG dinucleotides. But it is not yet known whether aging-related consensus …
Docosahexaenoic acid and cognition throughout the lifespan
Docosahexaenoic acid (DHA) is the predominant omega-3 (n-3) polyunsaturated fatty acid
(PUFA) found in the brain and can affect neurological function by modulating signal …
(PUFA) found in the brain and can affect neurological function by modulating signal …
The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease
Background Misfolding of microtubule-associated protein tau (MAPT) within neurons into
neurofibrillary tangles is an important pathological feature of Alzheimer's disease (AD). Tau …
neurofibrillary tangles is an important pathological feature of Alzheimer's disease (AD). Tau …
Deciphering the mechanism underlying late-onset Alzheimer disease
D Krstic, I Knuesel - Nature reviews neurology, 2013 - nature.com
Despite tremendous investments in understanding the complex molecular mechanisms
underlying Alzheimer disease (AD), recent clinical trials have failed to show efficacy. A …
underlying Alzheimer disease (AD), recent clinical trials have failed to show efficacy. A …
[HTML][HTML] Arizona study of aging and neurodegenerative disorders and brain and body donation program
Abstract The Brain and Body Donation Program (BBDP) at Banner Sun Health Research
Institute (http://www. brainandbodydonationprogram. org) started in 1987 with brain-only …
Institute (http://www. brainandbodydonationprogram. org) started in 1987 with brain-only …
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model
M Kitazawa, D Cheng, MR Tsukamoto… - The Journal of …, 2011 - journals.aai.org
Inflammation is a key pathological hallmark of Alzheimer's disease (AD), although its impact
on disease progression and neurodegeneration remains an area of active investigation …
on disease progression and neurodegeneration remains an area of active investigation …
Metformin–A future therapy for neurodegenerative diseases: Theme: Drug discovery, development and delivery in Alzheimer's disease Guest Editor: Davide Brambilla
M Markowicz-Piasecka, J Sikora, A Szydłowska… - Pharmaceutical …, 2017 - Springer
Type 2 diabetes mellitus (T2DM) is a complex, chronic and progressive metabolic disease,
which is characterized by relative insulin deficiency, insulin resistance, and high glucose …
which is characterized by relative insulin deficiency, insulin resistance, and high glucose …