Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

The environmentally important toxic metal, cadmium, exists as the Cd 2+ ion in biological
systems, and in this state structurally resembles Ca 2+. Thus, although cadmium exerts a …

The auxin-inducible degron (AID) system has emerged as a powerful tool to conditionally
deplete proteins in a range of organisms and cell types. Here, we describe a toolkit to …

Calcium-selective transient receptor potential vanilloid subfamily member 6 (TRPV6)
channels play a critical role in calcium uptake in epithelial tissues,,,. Altered TRPV6 …

TRPV6 is a calcium-selective ion channel implicated in epithelial Ca2+ uptake. TRPV6
inhibitors are needed for the treatment of a broad range of diseases associated with …

The cation-permeable TRPV2 channel is important for cardiac and immune cell function.
Cannabidiol (CBD), a non-psychoactive cannabinoid of clinical relevance, is one of the few …

Transient receptor potential (TRP) channels are involved in various physiological processes,
including sensory transduction. The TRP channel TRPV6 mediates calcium uptake in …

The changes in intracellular free calcium (Ca2+) levels are one of the most widely regulators
of cell function; therefore, calcium as a universal intracellular mediator is involved in very …

Calcium-selective channel TRPV6 (Transient Receptor Potential channel family, Vanilloid
subfamily member 6) belongs to the TRP family of cation channels and plays critical roles in …

Abstract Store-operated Ca 2+ entry (SOCE) through Ca 2+ release–activated Ca 2+(CRAC)
channels is essential for immunity to infection. CRAC channels are formed by ORAI1 …