Hedgehog ligands bind to protein patched homologue 1 (PTC), a conserved receptor that
activates the GLI family of transcription factors, which are involved in development, disease …

This overview provides insights into the molecular and cellular mechanisms involved in
guided bone regeneration, in particular focusing on aspects presented in the 3D movie, Cell …

Background Local ischemia and defective osteogenesis are implicated in the progression of
glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH). Recent studies …

The capacity for tissues to repair and regenerate diminishes with age. We sought to
determine the age-dependent contribution of native mesenchymal cells and circulating …

Hedgehog signaling is essential for bone formation, including functioning as a means for the
growth plate to drive skeletal mineralization. However, the mechanisms regulating …

Most bones in mammals display a limited capacity for natural large-scale repair. The ribs are
a notable exception, yet the source of their remarkable regenerative ability remains …

Tetracyclines (TCs) are a class of broad-spectrum antibiotics with diverse
pharmacotherapeutic properties due to their various functional groups being attached to a …

The healing of bone often involves a cartilage intermediate, yet how such cartilage is
induced and utilized during repair is not fully understood. By studying a model of large-scale …

The hedgehog (HH) signaling pathway is central to the regulation of bone development and
homeostasis. HH signaling is not only involved in osteoblast differentiation from bone …

Building and maintaining skeletal tissue requires the activity of skeletal stem and progenitor
cells (SSPCs). Following injury, local pools of these SSPCs become active and coordinate to …