In the course of examining the effect of electric fields on the growth of Escherichia coli cells,
a biological activity of platinum compounds was uncovered that led to the development of …

As the tale of p53 unfolds, it becomes ever more intriguing. Although our understanding of
the critical and complex roles played by p53 is progressing rapidly, new findings continue to …

Tumorigenesis is associated with enhanced cellular glucose uptake and increased
metabolism. Because the p53 tumor suppressor is mutated in a large number of cancers, we …

The tumour suppressor activity of the p53 protein has been explained by its ability to induce
apoptosis in response to a variety of cellular stresses,. Thus, understanding the mechanism …

From its modest beginnings in 1979, as a transformation-associated protein, to the
discoveries that p53 plays a key role in tumour suppression and in the cellular response to …

It is well established that induction of the p53 tumor suppressor protein in cells can lead to
either cell cycle arrest or apoptosis. To further understand features of p53 that contribute to …

Mutation of the p53 tumor suppressor gene is the most common genetic alteration in human
cancer. A majority of these mutations are missense mutations in the DNA-binding domain …

The p53 tumor suppressor is a transcriptional activator, with discrete domains that
participate in sequence-specific DNA binding, tetramerization, and transcriptional activation …

The tumor suppressor gene product p53 plays an important role in the cellular response to
DNA damage from exogenous chemical and physical mutagens. Therefore, we …

Volume 58 Issue 18 | Cancer Research | American Association for Cancer Research Skip to
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