Abnormal assembly of tau, α-synuclein, TDP-43 and amyloid-β proteins into amyloid
filaments defines most human neurodegenerative diseases. Genetics provides a direct link …

Neurofibrillary tangles, one of the neuropathologic hallmarks of Alzheimer's disease, have a
dynamic lifespan of maturity that associates with progressive neuronal dysfunction and …

Abundant filamentous inclusions of tau are characteristic of more than 20
neurodegenerative diseases that are collectively termed tauopathies. Electron cryo …

Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy that is
associated with repetitive head impacts or exposure to blast waves. First described as punch …

The ordered assembly of tau protein into abnormal filamentous inclusions underlies many
human neurodegenerative diseases. Tau assemblies seem to spread through specific …

Alzheimer's disease is the most common neurodegenerative disease, and there are no
mechanism-based therapies. The disease is defined by the presence of abundant …

The so-called amyloid hypothesis, that the accumulation and deposition of oligomeric or
fibrillar amyloid β (Aβ) peptide is the primary cause of Alzheimer's disease (AD), has been …

Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Alzheimer's disease (AD), a common neurodegenerative disease in the elderly and the most
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …