The immune response to an allograft activates lymphocytes with the capacity to cause
rejection. Activation of CD4+ CD25+ Foxp3+ T regulatory cells (Treg) can down-regulate …

Traditionally, T cells were CD4+ helper or CD8+ cytotoxic T cells, and with antibodies, they
were the soldiers of immunity. Now, many functionally distinct subsets of activated CD4+ and …

Resting and activated subpopulations of CD4+ CD25+ CD127loT regulatory cells (Treg) and
CD4+ CD25+ CD127+ effector T cells in MS patients and in healthy individuals were …

Regulatory T cells (Treg) mediate amelioration of disease and immune homeostasis by
inhibiting immune activation and maintaining peripheral immune tolerance. The suppressive …

Interleukin-4 (IL-4) has been considered as one of the tolerogenic cytokines in many
autoimmune animal models and clinical settings. Despite its role in antagonizing pathogenic …

A diverse suite of effector immune responses provide protection against various pathogens.
However, the array of effector responses must be immunologically regulated to limit …

Immune responses to foreign and self-Ags can be controlled by regulatory T cells (Tregs)
expressing CD4 and IL-2Rα chain (CD25). Defects in Tregs lead to autoimmunity, whereas …

In rat models, CD4+ CD25+ T regulatory cells (Treg) play a key role in the induction and
maintenance of antigen-specific transplant tolerance, especially in DA rats with PVG cardiac …

Kidney transplantation is the most common solid organ transplant and the best current
therapy for end-stage kidney failure. However, with standard immunosuppression, most …

Effector T cells have functional subpopulations with distinct cytokine, cytokine receptor,
chemokine receptor and transcription factors. We review how activation of antigen specific …