The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and
cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the …

The hematopoietic system composed of hematopoietic stem and progenitor cells (HSPCs)
and their differentiated lineages serves as an ideal model to uncover generic principles of …

Endothelial cells (ECs) line blood vessels and serve as a niche for hematopoietic stem and
progenitor cells (HSPCs). Recent data point to tissue-specific EC specialization as well as …

Greater amberjack (Seriola dumerili) is a fish species that has significant economic and
cultural value. It has a large size and grows rapidly. However, the intolerance to hypoxia …

DNA accessibility of cis-regulatory elements (CREs) dictates transcriptional activity and
drives cell differentiation during development. While many genes regulating embryonic …

Endothelial specification is a key event during embryogenesis; however, when, and how,
endothelial cells separate from other lineages is poorly understood. In zebrafish, Npas4l is …

The interplay between thrombosis and inflammation, termed thrombo-inflammation, causes
acute organ damage in diseases such as ischaemic stroke and venous thrombosis. We …

The establishment of distinct cellular identities was pivotal during the evolution of Metazoa,
enabling the emergence of an array of specialized tissues with different functions. In most …

Angiopoietin/TIE signalling plays a major role in blood and lymphatic vessel development. In
mouse, Tek (previously known as Tie2) mutants die prenatally due to a severely …

Colobomata, persistent optic fissures, frequently cause congenital blindness. Here, we
focused on optic fissure fusion using in vivo time-lapse imaging in zebrafish. We identified …