Snowflake-inspired and blink-driven flexible piezoelectric contact lenses for effective corneal injury repair

G Yao, X Mo, S Liu, Q Wang, M **e, W Lou… - Nature …, 2023 - nature.com
The cornea is a tissue susceptible to various injuries and traumas with a complicated
cascade repair process, in which conserving its integrity and clarity is critical to restoring …

Hyaluronan‐protein interactions: Lilliput revisited

AJ Day - Proteoglycan Research, 2024 - Wiley Online Library
Hyaluronan (HA) is a huge linear polysaccharide composed entirely of a simple repeating
disaccharide that has been preserved unchanged since the evolution of vertebrates~ 520 …

1, 5-Dicaffeoylquinic acid from Pseudognaphalium affine ameliorates dry eye disease via suppression of inflammation and protection of the ocular surface

CH Yoon, HJ Jang, JS Ryu, JH Ko, KS Ahn, SR Oh… - The Ocular Surface, 2023 - Elsevier
Purpose Pseudognaphalium affine (P. affine), a medicinal plant, has long been used to treat
various diseases due to its astringent and vulnerary effects. These therapeutic benefits are …

Endogenous TSG-6 modulates corneal inflammation following chemical injury

S Verma, IY Moreno, CP da Silva, M Sun, X Cheng… - The Ocular Surface, 2024 - Elsevier
Purpose Tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6) is upregulated in various
pathophysiological contexts, where it has a diverse repertoire of immunoregulatory …

Anti-inflammatory and wound healing potential of medicinal maggot excretions/secretions at the ocular surface

C Lema, H Baidouri, M Sun, S Pohl, S Cookson… - The Ocular Surface, 2022 - Elsevier
Abstract Purpose In the skin, Lucilia sericata maggot excretions/secretions (ES) accelerate
wound healing and limit inflammation. This study aimed to determine whether ES have …

Interferon-γ elicits the ocular surface pathology mimicking dry eye through direct modulation of resident corneal cells

JH Ko, S Kim, JS Ryu, HJ Song, JY Oh - Cell Death Discovery, 2023 - nature.com
Despite accumulating evidence indicating a key role of interferon-γ (IFN-γ)-producing
immune cells in ocular infection and immunity, little is known about the direct effects of IFN-γ …

Myeloid cells protect corneal nerves against sterile injury through negative-feedback regulation of TLR2–IL-6 axis

HJ Lee, HJ Kim, JH Ko, JY Oh - Journal of Neuroinflammation, 2023 - Springer
Background Mounting evidence suggests that the immune system plays detrimental or
protective roles in nerve injury and repair. Main body Herein we report that both …

[HTML][HTML] Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the …

Y Li, L Tian, S Li, X Chen, F Lei, J Bao, Q Wu… - Free Radical Biology …, 2024 - Elsevier
Purpose Severe dry eye disease causes ocular surface damage, which is highly associated
with mitochondrial dysfunction. Mitochondrial transcription factor A (TFAM) is essential for …

Toxicity and efficacy of type I interferons on the ocular surface: in vitro, animal, and clinical studies

YI Yun, JH Ko, JS Ryu, S Kim, HS Jeon, N Kim… - The Ocular Surface, 2024 - Elsevier
Purpose To investigate the toxicity of type I interferons (IFNs) on the ocular surface and
assess their efficacy in ocular surface tumors. Methods We examined the effects of IFN-α2a …

TSG-6 Inhibits the NF-κB Signaling Pathway and Promotes the Odontogenic Differentiation of Dental Pulp Stem Cells via CD44 in an Inflammatory Environment

Y Wang, Y **e, N Xue, H Xu, D Zhang, N Ji, Q Chen - Biomolecules, 2024 - mdpi.com
In pulpitis, dentinal restorative processes are considerably associated with undifferentiated
mesenchymal cells in the pulp. This study aimed to investigate strategies to improve the …